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Showing 1–9 of 9 results

Advanced filters: Author: Ivo Tews Clear advanced filters

Structure-guided disulfide engineering restricts antibody conformation to elicit TNFR agonism

Immunostimulatory antibodies have strong potential as anti-cancer therapeutics. Here Elliott et al. show that conformational rigidity determines agonistic activity of antibodies targeting CD40 and 4-1BB and demonstrate further enhancement of agonism through disulfide engineering.

Isabel G. Elliott
Hayden Fisher
Ivo Tews
ResearchOpen Access12 Apr 2025
Nature Communications

Volume: 16, P: 1-13
Bacterial chitobiase structure provides insight into catalytic mechanism and the basis of Tay–Sachs disease

Ivo Tews
Anastassis Perrakis
Constantin E. Vorgias
Research01 Jul 1996
Nature Structural Biology

Volume: 3, P: 638-648
Extensive substrate recognition by the streptococcal antibody-degrading enzymes IdeS and EndoS

The streptococcal enzymes IdeS and EndoS cleave IgG antibodies with exquisite substrate specificity, which has enabled their development as clinical and biotechnological tools. Here, the authors present crystal structures of both enzymes in complex with their IgG1 Fc substrate.

Abigail S. L. Sudol
John Butler
Max Crispin
ResearchOpen Access17 Dec 2022
Nature Communications

Volume: 13, P: 1-11
Lysine relay mechanism coordinates intermediate transfer in vitamin B6 biosynthesis

Crystallographic snapshots illustrate the catalytic cycle and illuminate the mechanism by which the enzyme Pdx1 shuttles intermediates between lysine residues in its two active sites during the biosynthesis of pyridoxal 5′-phosphate.

Matthew J Rodrigues
Volker Windeisen
Ivo Tews
Research16 Jan 2017
Nature Chemical Biology

Volume: 13, P: 290-294
Reducing affinity as a strategy to boost immunomodulatory antibody agonism

In contrast to direct-targeting monoclonal antibodies, low affinity confers agonistic monoclonal antibodies with more potency.

Xiaojie Yu
Christian M. Orr
Mark S. Cragg
Research01 Feb 2023
Nature

Volume: 614, P: 539-547
Differential impact on motility and biofilm dispersal of closely related phosphodiesterases in Pseudomonas aeruginosa

Yu-ming Cai
Andrew Hutchin
Ivo Tews
ResearchOpen Access10 Apr 2020
Scientific Reports

Volume: 10, P: 1-12
Dimerisation induced formation of the active site and the identification of three metal sites in EAL-phosphodiesterases

Dom Bellini
Sam Horrell
Martin A. Walsh
ResearchOpen Access10 Feb 2017
Scientific Reports

Volume: 7, P: 1-11
Agonistic CD27 antibody potency is determined by epitope-dependent receptor clustering augmented through Fc-engineering

Agonistic CD27 monoclonal antibodies can be used to enhance the efficacy of depleting antibodies such as anti-CTLA-4 in a colon adenocarcinoma tumour model. CD27 antibody agonism is dependent on isotype and epitope specificity.

Franziska Heckel
Anna H. Turaj
Sean H. Lim
ResearchOpen Access14 Mar 2022
Communications Biology

Volume: 5, P: 1-15
Characterization of two putative Dichelobacter nodosus footrot vaccine antigens identifies the first lysozyme inhibitor in the genus

Maria Victoria Humbert
Alexandra Jackson
Myron Christodoulides
ResearchOpen Access11 Jul 2019
Scientific Reports

Volume: 9, P: 1-14