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Advanced filters: Author: Ivy A. Kekessie Clear advanced filters

  • Discovery of macrocyclic ligands to the 19S regulatory particle protein PSMD2 enables the synthesis of heterobifunctional molecules that demonstrate proof-of-concept, targeted degradation of BRD4 through direct engagement of the 26S proteasome.

    • Charlene Bashore
    • Sumit Prakash
    • Erin C. Dueber
    ResearchOpen Access
    Nature Chemical Biology
    Volume: 19, P: 55-63