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Modeling and predicting mood instability in a longitudinal cohort of bipolar disorder

Sperry et al. used machine learning approaches to investigate profiles of mood instability and create a prediction model for clinical and functioning outcomes using data from the Prechter Longitudinal Study of Bipolar Disorder.

Audrey R. Stromberg
Anastasia K. Yocum
Sarah H. Sperry
Research22 Sept 2025
Nature Mental Health

Volume: 3, P: 1267-1275
iPS-cell-derived microglia promote brain organoid maturation via cholesterol transfer

The authors seek to understand the precise roles of microglia in the early human brain by coculturing brain organoids with primitive-like macrophages generated from the same human induced pluripotent stem cells (iMac).

Dong Shin Park
Tatsuya Kozaki
Florent Ginhoux
Research01 Nov 2023
Nature

Volume: 623, P: 397-405
Integrating de novo and inherited variants in 42,607 autism cases identifies mutations in new moderate-risk genes

An integrated analysis of de novo and inherited coding variants in 42,607 individuals with autism spectrum disorder identifies 60 risk genes of which five have not previously been associated with neurodevelopmental disorders.

Xueya Zhou
Pamela Feliciano
Wendy K. Chung
ResearchOpen Access18 Aug 2022
Nature Genetics

Volume: 54, P: 1305-1319
The electroencephalography protocol for the Accelerating Medicines Partnership® Schizophrenia Program: Reliability and stability of measures

Daniel H. Mathalon
Spero Nicholas
Gregory A. Light
ResearchOpen Access06 Jun 2025
Schizophrenia

Volume: 11, P: 1-18
Abnormal GABAergic Function and Negative Affect in Schizophrenia

Stephan F Taylor
Elise Demeter
Robert C Welsh
Research24 Oct 2013
Neuropsychopharmacology

Volume: 39, P: 1000-1008