Nature Search

The Ets transcription factor Spi-B is essential for the differentiation of intestinal microfold cells

Intestinal microfold (M) cells actively capture luminal antigens and move them by transcytosis to initiate immune responses. Ohno and colleagues show that the Ets transcription factor Spi-B is necessary for M-cell differentiation.

Takashi Kanaya
Koji Hase
Hiroshi Ohno
Research17 Jun 2012
Nature Immunology

Volume: 13, P: 729-736
CD8⁺ regulatory T cells are critical in prevention of autoimmune-mediated diabetes

Helminth infections are associated with a reduction in inflammatory pathology in rodent models of type 1 diabetes. Here, the authors show patient data and that trehalose (produced by H. polygyrus) can alter the microbiome of mice, inducing regulatory CD8⁺ T cells and reducing susceptibility to autoimmune diabetes.

Chikako Shimokawa
Tamotsu Kato
Hajime Hisaeda
ResearchOpen Access22 Apr 2020
Nature Communications

Volume: 11, P: 1-9
Renoprotective Effect and Cost-Effectiveness of Using Benidipine, a Calcium Channel Blocker, to Lower the Dose of Angiotensin Receptor Blocker in Hypertensive Patients with Albumiuria

Fumio Saito
Hirotaka Fujita
Toshio Kushiro
Research01 Jan 2007
Hypertension Research

Volume: 30, P: 39-47
Ultrafast permeation of water through protein-based membranes

Porous membranes are widely used as filters for the production of clean drinking water. A new type of filtration membrane made of crosslinked proteins can cope with water fluxes that are three orders of magnitude higher than those that can be handled by commercial filtration membranes with similar rejection properties.

Xinsheng Peng
Jian Jin
Izumi Ichinose
Research26 Apr 2009
Nature Nanotechnology

Volume: 4, P: 353-357
Stratifin as a novel diagnostic biomarker in serum for diffuse alveolar damage

No reliable serum biomarker for diffuse alveolar damage, a poor prognosis subtype of drug-induced interstitial lung disease, is currently available. Here, the authors show stratifin/14-3-3σ in serum is a promising biomarker for diagnosis of this type of disease.

Noriaki Arakawa
Atsuhito Ushiki
Masayuki Hanaoka
ResearchOpen Access04 Oct 2022
Nature Communications

Volume: 13, P: 1-16
Specific Y14 domains mediate its nucleo-cytoplasmic shuttling and association with spliced mRNA

Naoyuki Kataoka
Michael D. Diem
Mutsuhito Ohno
ResearchOpen Access14 Sept 2011
Scientific Reports

Volume: 1, P: 1-7
hDbr1 is a nucleocytoplasmic shuttling protein with a protein phosphatase-like motif essential for debranching activity

Naoyuki Kataoka
Izumi Dobashi
Mutsuhito Ohno
ResearchOpen Access21 Jan 2013
Scientific Reports

Volume: 3, P: 1-7
Diagnostic value of IMP3 and p53 immunohistochemical staining in EUS-guided fine-needle aspiration for solid pancreatic tumors

Rintaro Mikata
Shin Yasui
Naoya Kato
ResearchOpen Access26 Aug 2021
Scientific Reports

Volume: 11, P: 1-9
Preparation of Cross-Linked Ultrathin Films Based on Layer-by-Layer Assembly of Polymers

Izumi Ichinose
Suguru Mizuki
Toyoki Kunitake
Research01 Nov 1999
Polymer Journal

Volume: 31, P: 1065-1070
Microbiota-derived lactate accelerates colon epithelial cell turnover in starvation-refed mice

Epithelial cells in the colon mainly use microbial fermentation products as energy sources. Here Okada et al. find that lactate produced by commensal Lactobacillus murinusregulates colonic epithelial cell proliferation and show that mice are more susceptible to carcinogens when refed after a period of starvation.

Toshihiko Okada
Shinji Fukuda
Taeko Dohi
Research03 Apr 2013
Nature Communications

Volume: 4, P: 1-10
Effects of Eplerenone and Salt Intake on Left Ventricular Remodeling after Myocardial Infarction in Rats

Akihiro Urabe
Takehiko Izumi
Seibu Mochizuki
Research01 Aug 2006
Hypertension Research

Volume: 29, P: 627-634
Approaches to diagnostic screening for congenital disorders of glycosylation and its prevalence in Japan

Nobuhiko Okamoto
Machiko Kadoya
Yoshinao Wada
Reviews02 Jul 2025
Journal of Human Genetics

P: 1-6
Annexin II represents metastatic potential in clear-cell renal cell carcinoma

Y Ohno
M Izumi
M Tachibana
ResearchOpen Access09 Jun 2009
British Journal of Cancer

Volume: 101, P: 287-294
Phase II study comparing nasal pressure monitoring with capnography during invasive endoscopic procedures: a single-center, single-arm trial

Hiroki Nagashima
Rintaro Mikata
Naoya Kato
ResearchOpen Access23 Jan 2023
Scientific Reports

Volume: 13, P: 1-10
Cortico-striatal activity associated with fidget spinner use: an fMRI study

Suzuka Narukawa
Momoka Nishimura
Shota A. Murai
ResearchOpen Access22 Sept 2023
Scientific Reports

Volume: 13, P: 1-10
“Salvage techniques” are the key to overcome difficult biliary cannulation in endoscopic retrograde cholangiopancreatography

Shikiko Maruta
Harutoshi Sugiyama
Naoya Kato
ResearchOpen Access10 Aug 2022
Scientific Reports

Volume: 12, P: 1-10
Identification and characterization of lysophosphatidylcholine 14:0 as a biomarker for drug-induced lung disease

Kosuke Saito
Akihiko Gemma
Masayuki Hanaoka
ResearchOpen Access17 Nov 2022
Scientific Reports

Volume: 12, P: 1-12
Solar abundance ratios of the iron-peak elements in the Perseus cluster

High-resolution X-ray spectra show near-solar abundances of chromium, manganese and nickel with respect to iron in the Perseus cluster, suggesting that the progenitors of type Ia supernovae could be near- and sub-Chandrasekhar-mass white dwarfs.

Felix Aharonian
Hiroki Akamatsu
Abderahmen Zoghbi
Research01 Nov 2017
Nature

Volume: 551, P: 478-480
Serum alpha-fetoprotein and clinical outcomes in patients with advanced hepatocellular carcinoma treated with ramucirumab

Andrew X. Zhu
Richard S. Finn
Masatoshi Kudo
ResearchOpen Access03 Feb 2021
British Journal of Cancer

Volume: 124, P: 1388-1397
HLA genotype-clinical phenotype correlations in multiple sclerosis and neuromyelitis optica spectrum disorders based on Japan MS/NMOSD Biobank data

Mitsuru Watanabe
Yuri Nakamura
Jun-ichi Kira
ResearchOpen Access12 Jan 2021
Scientific Reports

Volume: 11, P: 1-16
Reduction of leukemia cell burden and restoration of normal hematopoiesis at 3 months of crizotinib treatment in RAN-binding protein 2 (RANBP2)–anaplastic lymphoma kinase (ALK) acute myeloid leukemia

Y Maesako
A Okumura
H Ohno
Correspondence21 May 2014
Leukemia

Volume: 28, P: 1935-1937
Pre-transplant imatinib-based therapy improves the outcome of allogeneic hematopoietic stem cell transplantation for BCR–ABL-positive acute lymphoblastic leukemia

S Mizuta
K Matsuo
R Ohno
Research14 Oct 2010
Leukemia

Volume: 25, P: 41-47

Search

The Ets transcription factor Spi-B is essential for the differentiation of intestinal microfold cells

CD8⁺ regulatory T cells are critical in prevention of autoimmune-mediated diabetes

Renoprotective Effect and Cost-Effectiveness of Using Benidipine, a Calcium Channel Blocker, to Lower the Dose of Angiotensin Receptor Blocker in Hypertensive Patients with Albumiuria

Ultrafast permeation of water through protein-based membranes

Stratifin as a novel diagnostic biomarker in serum for diffuse alveolar damage

Specific Y14 domains mediate its nucleo-cytoplasmic shuttling and association with spliced mRNA

hDbr1 is a nucleocytoplasmic shuttling protein with a protein phosphatase-like motif essential for debranching activity

Diagnostic value of IMP3 and p53 immunohistochemical staining in EUS-guided fine-needle aspiration for solid pancreatic tumors

Preparation of Cross-Linked Ultrathin Films Based on Layer-by-Layer Assembly of Polymers

Microbiota-derived lactate accelerates colon epithelial cell turnover in starvation-refed mice

Effects of Eplerenone and Salt Intake on Left Ventricular Remodeling after Myocardial Infarction in Rats

Approaches to diagnostic screening for congenital disorders of glycosylation and its prevalence in Japan

Annexin II represents metastatic potential in clear-cell renal cell carcinoma

Phase II study comparing nasal pressure monitoring with capnography during invasive endoscopic procedures: a single-center, single-arm trial

Cortico-striatal activity associated with fidget spinner use: an fMRI study

“Salvage techniques” are the key to overcome difficult biliary cannulation in endoscopic retrograde cholangiopancreatography

Identification and characterization of lysophosphatidylcholine 14:0 as a biomarker for drug-induced lung disease

Solar abundance ratios of the iron-peak elements in the Perseus cluster

Serum alpha-fetoprotein and clinical outcomes in patients with advanced hepatocellular carcinoma treated with ramucirumab

HLA genotype-clinical phenotype correlations in multiple sclerosis and neuromyelitis optica spectrum disorders based on Japan MS/NMOSD Biobank data

Reduction of leukemia cell burden and restoration of normal hematopoiesis at 3 months of crizotinib treatment in RAN-binding protein 2 (RANBP2)–anaplastic lymphoma kinase (ALK) acute myeloid leukemia

Pre-transplant imatinib-based therapy improves the outcome of allogeneic hematopoietic stem cell transplantation for BCR–ABL-positive acute lymphoblastic leukemia

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