Nature Search

Opposite physiological and pathological mTORC1-mediated roles of the CB1 receptor in regulating renal tubular function

Renal proximal tubules modulate whole-body homeostasis by sensing various nutrients. Here the authors describe the existence and importance of a unique CB1/mTORC1/GLUT2 signaling axis in regulating nutrient homeostasis in healthy and diseased kidney.

Liad Hinden
Majdoleen Ahmad
Joseph Tam
ResearchOpen Access04 Apr 2022
Nature Communications

Volume: 13, P: 1-18
Mechanism of substrate transport and inhibition of the human LAT1-4F2hc amino acid transporter

Renhong Yan
Yaning Li
Qiang Zhou
ResearchOpen Access23 Mar 2021
Cell Discovery

Volume: 7, P: 1-8
Cannabinoid CB₂ receptor ligand profiling reveals biased signalling and off-target activity

CB₂ receptor agonists are developed as potential analgesics or immune-modulatory compounds. Here, the authors characterize the pharmacological properties of widely used CB₂ receptor agonists and antagonists, recommending three that appear most suitable for in vitro and in vivostudies.

Marjolein Soethoudt
Uwe Grether
Mario van der Stelt
ResearchOpen Access03 Jan 2017
Nature Communications

Volume: 8, P: 1-14
Structural insights into the mechanism and dynamics of proteorhodopsin biogenesis and retinal scavenging

Microbial rhodopsins are prevalent retinal-binding membrane proteins. Here, authors reveal the roles of the N-terminal signal peptide in oligomerization and of decanoate as a retinal placeholder, providing proteorhodopsin structures and retinal incorporation mechanisms.

Stephan Hirschi
Thomas Lemmin
Dimitrios Fotiadis
ResearchOpen Access13 Aug 2024
Nature Communications

Volume: 15, P: 1-13
Scaffold and organism hopping with chemical probes

Chemical probes that irreversibly inhibit protein function may be used across species to discover proteins. Combining phenotypic screening and activity-based protein profiling, a new study uncovers a discrete lipid signaling pathway regulating lifespan in the worm Caenorhabditis elegans.

Jürg Gertsch
News & Views16 Apr 2019
Nature Chemical Biology

Volume: 15, P: 428-429
Pepcan-12 (RVD-hemopressin) is a CB2 receptor positive allosteric modulator constitutively secreted by adrenals and in liver upon tissue damage

Vanessa Petrucci
Andrea Chicca
Jürg Gertsch
ResearchOpen Access25 Aug 2017
Scientific Reports

Volume: 7, P: 1-14
Mitochondrial CB₁ receptors regulate neuronal energy metabolism

The authors show that the type-1 cannabinoid receptor (CB₁) is present in mouse neuronal mitochondrial membranes. They show that mitochondrial CB₁ receptors regulate cellular respiration and energy production in the brain and may contribute to synaptic plasticity in the hippocampus.

Giovanni Bénard
Federico Massa
Giovanni Marsicano
Research04 Mar 2012
Nature Neuroscience

Volume: 15, P: 558-564
Targeted metabolomics shows plasticity in the evolution of signaling lipids and uncovers old and new endocannabinoids in the plant kingdom

María Salomé Gachet
Alexandra Schubert
Jürg Gertsch
ResearchOpen Access25 Jan 2017
Scientific Reports

Volume: 7, P: 1-15
Endocannabinoids and related lipids linked to social exclusion in individuals with chronic non-medical prescription opioid use

Sara L. Kroll
Philip Meier
Boris B. Quednow
ResearchOpen Access21 May 2024
Neuropsychopharmacology

Volume: 49, P: 1630-1639
Neuropsychopharmacological profiling of scoparone in mice

Joanna Kowalczyk
Barbara Budzyńska
Krystyna Skalicka-Woźniak
ResearchOpen Access17 Jan 2022
Scientific Reports

Volume: 12, P: 1-13
The ACSL3-LPIAT1 signaling drives prostaglandin synthesis in non-small cell lung cancer

Maria Saliakoura
Inés Reynoso-Moreno
Georgia Konstantinidou
ResearchOpen Access07 Feb 2020
Oncogene

Volume: 39, P: 2948-2960
Dysfunction of homeostatic control of dopamine by astrocytes in the developing prefrontal cortex leads to cognitive impairments

Francesco Petrelli
Glenn Dallérac
Paola Bezzi
ResearchOpen Access20 Aug 2018
Molecular Psychiatry

Volume: 25, P: 732-749

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