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Showing 1–9 of 9 results
Advanced filters: Author: J Alexander Heimel Clear advanced filters

  • The critical period of ocular dominance (OD) plasticity in the visual cortex is initiated by maturation of inhibition. The authors show that thalamic relay neurons in mouse dorsolateral geniculate nucleus also undergo OD plasticity. This process depends on thalamic inhibition and is required for consolidating the OD shift in visual cortex.

    • Jean-Pierre Sommeijer
    • Mehran Ahmadlou
    • Christiaan N. Levelt
    Research
    Nature Neuroscience
    Volume: 20, P: 1715-1721

  • How myelin plays a role in long-range processing of disparate inputs remains elusive. Here, the authors show that myelin loss within the neocortex reduces the reliability to propagate cortical bursts across axons, causing an impaired temporal sharpening to compute sensory and cortical signals within the thalamus.

    • Nora Jamann
    • Jorrit S. Montijn
    • Maarten H. P. Kole
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-20

  • The mammalian superior colliculus (SC) processes visual stimuli but little is known about the spatial organization of the response preferences for specific visual features. Here the authors show that the mouse SC contains a map for orientation preference such that preferred grating orientation is aligned to concentric circles around the centre of the visual field.

    • Mehran Ahmadlou
    • J Alexander Heimel
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-11

  • The role of the superior colliculus (SC) in modulating V1 cortical activity is not clear. Here, the authors demonstrate the functional role of SC in modulating V1 responses through an excitatory pathway via the dorsal lateral geniculate nucleus.

    • Mehran Ahmadlou
    • Larry S. Zweifel
    • J. Alexander Heimel
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-13

  • When monolayers of π-conjugated organic semiconductors interact with metal surfaces, most remain semiconducting. In some cases, however, the metallic character of the substrate is seen to extend onto the molecules. A mechanism for this intriguing phenomenon is now suggested and new strategies for chemical surface engineering are proposed.

    • G. Heimel
    • S. Duhm
    • N. Koch
    Research
    Nature Chemistry
    Volume: 5, P: 187-194

  • In addition to the neurotropic role of brain-derived neurotrophic factor (BNDF) in cortical circuit plasticity, there is a good positive correlation between the cortical expression level of BDNF and developmental changes in visual acuity. Here, the authors find that directly impairing BDNF signaling using transgenic methods causes visual impairment by affecting the systems level control on contrast gain.

    • J Alexander Heimel
    • M Hadi Saiepour
    • Christiaan N Levelt
    Research
    Nature Neuroscience
    Volume: 13, P: 642-648

  • Molecular diversity of proprioceptive neuron types (Ia, Ib and II PNs) is unclear. Here, the authors characterized the functional organization and development of eight subtypes of PNs in mice. Importantly, Ia subtypes are plastic, suggesting a role in adaptive proprioception during motor behavior.

    • Haohao Wu
    • Charles Petitpré
    • François Lallemend
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-13