While EGFR tyrosine kinase inhibitors (TKIs) are often effective in EGFR mutant lung cancer, resistance often occurs. Here, the authors identify intratumoural heterogeneity of EGFR expression and find that EGFR-low cells are more tolerant to EGFR-TKI, promoting resistance.
- Bassel Alsaed
- Linh Lin
- Heidi M. Haikala
