One of two papers in this issue that identifies enzymes capable of demethylating a tri-methyl group from Lys 9 of histone H3 — a mark required for the establishment of heterochromatin and previously considered to be stable. JHDM3A, a member of the JMJD2 enzyme family, can disrupt heterochromatin structure when overexpressed and may function in euchromatin to regulate transcription.
- Robert J. Klose
- Kenichi Yamane
- Yi Zhang
