Nature Search

Shared neutrophil and T cell dysfunction is accompanied by a distinct interferon signature during severe febrile illnesses in children

Severe febrile illnesses in children may be various in presentation and aetiology but involve immune dysfunction amenable to immunomodulation. Here, the authors identify shared neutrophil and T cell dysfunction and a distinct interferon signature in critically ill children with severe febrile illness.

Harsita Patel
Michael J. Carter
Leire Estamiana Elorieta
ResearchOpen Access19 Sept 2024
Nature Communications

Volume: 15, P: 1-16
Hyperactivation of HUSH complex function by Charcot–Marie–Tooth disease mutation in MORC2

Paul Lehner and colleagues identify an essential role for MORC2 in HUSH complex–mediated epigenetic silencing. They show that loss of MORC2 causes chromatin decompaction at HUSH-target loci and that a MORC2 mutation that causes Charcot–Marie–Tooth disease results in hyperactivation of HUSH-mediated repression in neuronal cells.

Iva A Tchasovnikarova
Richard T Timms
Paul J Lehner
Research05 Jun 2017
Nature Genetics

Volume: 49, P: 1035-1044
Solar wind contributions to Earth’s oceans

Water and hydroxyl enrichment in the solar-wind-irradiated rim of an olivine grain from asteroid Itokawa suggests that its regolith could contain ~20 l m⁻³ of water from solar wind—a potential water source for airless planetary bodies.

Luke Daly
Martin R. Lee
Michelle S. Thompson
Research29 Nov 2021
Nature Astronomy

Volume: 5, P: 1275-1285
Duns, Spinners and Sedges

J. W. MUNRO
Books & Arts21 Feb 1953
Nature

Volume: 171, P: 320-321
Vigabatrin-associated visual field defects in children

I M Russell-Eggitt
D A Mackey
J W Walker
Research01 May 2000
Eye

Volume: 14, P: 334-339
Simplified and objective assessment of spermatogenesis in spinal cord injured men by flow cytometry analysis

I H Hirsch
D Kulp-Hugues
W E Staas
Research01 Dec 1993
Spinal Cord

Volume: 31, P: 785-792
Disulfide-activated protein kinase G Iα regulates cardiac diastolic relaxation and fine-tunes the Frank–Starling response

The stroke volume of the heart increases in response to an increase in the blood volume filling the heart. Here the authors reveal that this coordinated process is mediated in part by oxidative activation of the protein kinase G Iα, which phosphorylates phospholamban to enhance diastolic relaxation in mice.

Jenna Scotcher
Oleksandra Prysyazhna
Philip Eaton
ResearchOpen Access26 Oct 2016
Nature Communications

Volume: 7, P: 1-11
Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing

Analysis of whole-genome sequencing data across 2,658 tumors spanning 38 cancer types shows that chromothripsis is pervasive, with a frequency of more than 50% in several cancer types, contributing to oncogene amplification, gene inactivation and cancer genome evolution.

Isidro Cortés-Ciriano
Jake June-Koo Lee
Christian von Mering
ResearchOpen Access05 Feb 2020
Nature Genetics

Volume: 52, P: 331-341
Comprehensive molecular characterization of mitochondrial genomes in human cancers

Analysis of mitochondrial genomes (mtDNA) by using whole-genome sequencing data from 2,658 cancer samples across 38 cancer types identifies hypermutated mtDNA cases, frequent somatic nuclear transfer of mtDNA and high variability of mtDNA copy number in many cancers.

Yuan Yuan
Young Seok Ju
Christian von Mering
ResearchOpen Access05 Feb 2020
Nature Genetics

Volume: 52, P: 342-352
Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes

Exome sequencing and copy number analysis are used to define genomic aberrations in early sporadic pancreatic ductal adenocarcinoma; among the findings are mutations in genes involved in chromatin modification and DNA damage repair, and frequent and diverse somatic aberrations in genes known as embryonic regulators of axon guidance.

Andrew V. Biankin
Nicola Waddell
Sean M. Grimmond
Research24 Oct 2012
Nature

Volume: 491, P: 399-405
Butler enables rapid cloud-based analysis of thousands of human genomes

Efficient, large-scale genomic analysis is facilitated on the cloud by a computational tool with error-diagnosing and self-healing capabilities.

Sergei Yakneen
Sebastian M. Waszak
Christian von Mering
ResearchOpen Access05 Feb 2020
Nature Biotechnology

Volume: 38, P: 288-292
Haploinsufficiency of SF3B2 causes craniofacial microsomia

Despite being a common congenital facial anomaly, the genetic etiology of craniofacial microsomia (CFM) is not well understood. Here, the authors use exome and genome sequencing of 146 individuals with CFM to identify haploinsufficient variants in SF3B2 as a prevalent underlying cause.

Andrew T. Timberlake
Casey Griffin
Daniela V. Luquetti
ResearchOpen Access03 Aug 2021
Nature Communications

Volume: 12, P: 1-11
Reference Book of Interferometers

K. J. HABELL
Books & Arts21 Feb 1953
Nature

Volume: 171, P: 321
Genomic hallmarks of localized, non-indolent prostate cancer

Genomic analyses of localized, non-indolent prostate cancer identify recurrent aberrations that can predict relapse, and also highlight differences between early prostate cancer and metastatic, castration-resistant disease.

Michael Fraser
Veronica Y. Sabelnykova
Paul C. Boutros
Research09 Jan 2017
Nature

Volume: 541, P: 359-364
OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis

Young-Yun Kong
Hiroki Yoshida
Josef M. Penninger
Research28 Jan 1999
Nature

Volume: 397, P: 315-323
The DNA sequence of the human X chromosome

Mark T. Ross
Darren V. Grafham
David R. Bentley
Research17 Mar 2005
Nature

Volume: 434, P: 325-337
Landscape of somatic single nucleotide variants and indels in colorectal cancer and impact on survival

Large scale sequencing study is of paramount importance to unravel the heterogeneity of colorectal cancer. Here, the authors sequenced 205 cancer genes in more than 2000 tumours and identified additional mutated driver genes, determined that mutational burden and specific mutations in TP53 are associated with survival odds.

Syed H. Zaidi
Tabitha A. Harrison
Ulrike Peters
ResearchOpen Access20 Jul 2020
Nature Communications

Volume: 11, P: 1-12
Spatial genomic heterogeneity within localized, multifocal prostate cancer

Paul Boutros, Robert Bristow and colleagues report a molecular analysis of the spatial heterogeneity of clinically localized, multifocal prostate cancer. They find that multifocal tumors are highly heterogeneous, and they identify a novel recurrent amplification of MYCL1.

Paul C Boutros
Michael Fraser
Robert G Bristow
Research25 May 2015
Nature Genetics

Volume: 47, P: 736-745
Epstein–Barr virus can inhibit genotoxin-induced G1 arrest downstream of p53 by preventing the inactivation of CDK2

Jenny O'Nions
Martin J Allday
Research16 Oct 2003
Oncogene

Volume: 22, P: 7181-7191
Retroviral integrations contribute to elevated host cancer rates during germline invasion

Koalas are susceptible to neoplasms, which are related to infection with the Koala retrovirus. Here, the authors use DNA sequencing to show that the retroviral insertion sites cluster near known cancer genes and demonstrate a high mutational load associated with the germline invasion of the virus.

Gayle K. McEwen
David E. Alquezar-Planas
Alex D. Greenwood
ResearchOpen Access26 Feb 2021
Nature Communications

Volume: 12, P: 1-13
Evaluation of Chlamydia pecorum major outer membrane protein vaccine a management tool in wild koala (Phascolarctos cinereus) populations

Sarah J. Simpson
Damien P. Higgins
Mark B. Krockenberger
ResearchOpen Access20 Aug 2025
Scientific Reports

Volume: 15, P: 1-13
Expression of MHC class II, interleukin 2 receptor and CD45 antigens on tumour-associated T lymphocytes in colonic carcinoma

MN Norazmi
AW Hohmann
J Bradley
Research01 Nov 1989
British Journal of Cancer

Volume: 60, P: 685-687
Neuropathic MORC2 mutations perturb GHKL ATPase dimerization dynamics and epigenetic silencing by multiple structural mechanisms

Microrchidia CW-type zinc finger protein 2 (MORC2) is an effector of epigenetic silencing by the human silencing hub (HUSH). Here the authors present the crystal structures of MORC2 and disease-causing MORC2 mutants and give mechanistic insights into how MORC2 mediates HUSH-dependent silencing.

Christopher H. Douse
Stuart Bloor
Yorgo Modis
ResearchOpen Access13 Feb 2018
Nature Communications

Volume: 9, P: 1-15
Engineering Dimensional Metrology: Symposium at the National Physical Laboratory

T. R. J. OAKLEY
News13 Feb 1954
Nature

Volume: 173, P: 293-295
Gene gain facilitated endosymbiotic evolution of Chlamydiae

Extensive gene gain via horizontal gene transfer facilitated the evolution of obligate intracellular Chlamydiae.

Jennah E. Dharamshi
Stephan Köstlbacher
Matthias Horn
ResearchOpen Access05 Jan 2023
Nature Microbiology

Volume: 8, P: 40-54
Degrons: defining the rules of protein degradation

Degrons allow E3 ubiquitin ligases to identify their substrates, and thus have a central role in protein degradation by the ubiquitin–proteasome system. This Review discusses the latest insights into the mechanisms underlying degron function, the relevance of degrons in disease and how degrons can be harnessed for therapeutic protein degradation.

Zhiqian Zhang
Elijah L. Mena
Stephen J. Elledge
Reviews14 Jul 2025
Nature Reviews Molecular Cell Biology

Volume: 26, P: 868-883
Host Influence on Parasite Physiology

J. D. FULTON
News26 Mar 1960
Nature

Volume: 185, P: 897-899
A recurrent germline PAX5 mutation confers susceptibility to pre-B cell acute lymphoblastic leukemia

Marshall Horwitz, Charles Mullighan, Kenneth Offit and colleagues report the identification of a recurrent germline PAX5 mutation in families with pre–B cell acute lymphoblastic leukemia. They also identify sporadic cases of this leukemia with the same mutation that arose somatically.

Sohela Shah
Kasmintan A Schrader
Kenneth Offit
Research08 Sept 2013
Nature Genetics

Volume: 45, P: 1226-1231
Author Correction: Disruption of chromatin folding domains by somatic genomic rearrangements in human cancer

Kadir C. Akdemir
Victoria T. Le
Christian von Mering
Amendments and CorrectionsOpen Access21 Mar 2023
Nature Genetics

Volume: 55, P: 1079
Author Correction: Butler enables rapid cloud-based analysis of thousands of human genomes

Sergei Yakneen
Sebastian M. Waszak
Christian von Mering
Amendments and CorrectionsOpen Access21 Mar 2023
Nature Biotechnology

Volume: 41, P: 577
Author Correction: Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition

Bernardo Rodriguez-Martin
Eva G. Alvarez
Christian von Mering
Amendments and CorrectionsOpen Access21 Mar 2023
Nature Genetics

Volume: 55, P: 1080
Author Correction: Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing

Isidro Cortés-Ciriano
Jake June-Koo Lee
Christian von Mering
Amendments and CorrectionsOpen Access21 Mar 2023
Nature Genetics

Volume: 55, P: 1076
Candidate biomarkers of PARP inhibitor sensitivity in ovarian cancer beyond the BRCA genes

Darren R. Hodgson
Brian A. Dougherty
J. Carl Barrett
ResearchOpen Access24 Oct 2018
British Journal of Cancer

Volume: 119, P: 1401-1409
Author Correction: Comprehensive molecular characterization of mitochondrial genomes in human cancers

Yuan Yuan
Young Seok Ju
Christian von Mering
Amendments and CorrectionsOpen Access21 Mar 2023
Nature Genetics

Volume: 55, P: 1078
Author Correction: Reconstructing evolutionary trajectories of mutation signature activities in cancer using TrackSig

Yulia Rubanova
Ruian Shi
Christian von Mering
Amendments and CorrectionsOpen Access08 Dec 2022
Nature Communications

Volume: 13, P: 1
Author Correction: Combined burden and functional impact tests for cancer driver discovery using DriverPower

Shimin Shuai
Federico Abascal
Christian von Mering
Amendments and CorrectionsOpen Access08 Dec 2022
Nature Communications

Volume: 13, P: 1
Author Correction: Pathway and network analysis of more than 2500 whole cancer genomes

Matthew A. Reyna
David Haan
Christian von Mering
Amendments and CorrectionsOpen Access08 Dec 2022
Nature Communications

Volume: 13, P: 1
Author Correction: Genomic basis for RNA alterations in cancer

Claudia Calabrese
Natalie R. Davidson
Christian von Mering
Amendments and CorrectionsOpen Access25 Jan 2023
Nature

Volume: 614, P: E37
Author Correction: Genomic footprints of activated telomere maintenance mechanisms in cancer

Lina Sieverling
Chen Hong
Christian von Mering
Amendments and CorrectionsOpen Access08 Dec 2022
Nature Communications

Volume: 13, P: 1
Author Correction: Integrative pathway enrichment analysis of multivariate omics data

Marta Paczkowska
Jonathan Barenboim
Christian von Mering
Amendments and CorrectionsOpen Access08 Dec 2022
Nature Communications

Volume: 13, P: 1
Author Correction: High-coverage whole-genome analysis of 1220 cancers reveals hundreds of genes deregulated by rearrangement-mediated cis-regulatory alterations

Yiqun Zhang
Fengju Chen
Christian von Mering
Amendments and CorrectionsOpen Access08 Dec 2022
Nature Communications

Volume: 13, P: 1
Author Correction: Analyses of non-coding somatic drivers in 2,658 cancer whole genomes

Esther Rheinbay
Morten Muhlig Nielsen
Christian von Mering
Amendments and CorrectionsOpen Access25 Jan 2023
Nature

Volume: 614, P: E40
Author Correction: Patterns of somatic structural variation in human cancer genomes

Yilong Li
Nicola D. Roberts
Christian von Mering
Amendments and CorrectionsOpen Access25 Jan 2023
Nature

Volume: 614, P: E38
Author Correction: The landscape of viral associations in human cancers

Marc Zapatka
Ivan Borozan
Christian von Mering
Amendments and CorrectionsOpen Access21 Mar 2023
Nature Genetics

Volume: 55, P: 1077
Author Correction: The repertoire of mutational signatures in human cancer

Ludmil B. Alexandrov
Jaegil Kim
Christian von Mering
Amendments and CorrectionsOpen Access25 Jan 2023
Nature

Volume: 614, P: E41
Author Correction: Inferring structural variant cancer cell fraction

Marek Cmero
Ke Yuan
Christian von Mering
Amendments and CorrectionsOpen Access08 Dec 2022
Nature Communications

Volume: 13, P: 1
Author Correction: The evolutionary history of 2,658 cancers

Moritz Gerstung
Clemency Jolly
Christian von Mering
Amendments and CorrectionsOpen Access25 Jan 2023
Nature

Volume: 614, P: E42
Author Correction: A deep learning system accurately classifies primary and metastatic cancers using passenger mutation patterns

Wei Jiao
Gurnit Atwal
Christian von Mering
Amendments and CorrectionsOpen Access08 Dec 2022
Nature Communications

Volume: 13, P: 1
Peripheral immunophenotypes in children with multisystem inflammatory syndrome associated with SARS-CoV-2 infection

Characterization of a cohort of children with multisystem inflammatory syndrome associated with SARS-CoV-2 infection provides insights into the immunopathogenic features of the disease.

Michael J. Carter
Matthew Fish
Manu Shankar-Hari
Research18 Aug 2020
Nature Medicine

Volume: 26, P: 1701-1707
Author Correction: Divergent mutational processes distinguish hypoxic and normoxic tumours

Vinayak Bhandari
Constance H. Li
Christian von Mering
Amendments and CorrectionsOpen Access08 Dec 2022
Nature Communications

Volume: 13, P: 1

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