Nature Search

Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer

P J Roberts
C J Der
Reviews14 May 2007
Oncogene

Volume: 26, P: 3291-3310
CL100 expression is down-regulated in advanced epithelial ovarian cancer and its re-expression decreases its malignant potential

Ramon G Manzano
Luis M Montuenga
Michael J Birrer
Research25 Jun 2002
Oncogene

Volume: 21, P: 4435-4447
Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia

Mikael J.L. Eliasson
Kenji Sampei
Valina L. Dawson
Research01 Oct 1997
Nature Medicine

Volume: 3, P: 1089-1095
Direct integrin αvβ6-ERK binding: implications for tumour growth

Nuzhat Ahmed
Jun Niu
Michael V Agrez
Research21 Feb 2002
Oncogene

Volume: 21, P: 1370-1380
ERK1/2 is activated in non-small-cell lung cancer and associated with advanced tumours

S Vicent
J M López-Picazo
L M Montuenga
ResearchOpen Access02 Mar 2004
British Journal of Cancer

Volume: 90, P: 1047-1052
MEK1 and MEK2 inhibitors and cancer therapy: the long and winding road

MEK1 and MEK2 have key roles in tumorigenesis and, therefore, represent promising targets for cancer therapy. This Review discusses the mechanisms of action of different inhibitors of MEK1 and MEK2, the mechanisms of resistance to these inhibitors and their current clinical progress.

Christopher J. Caunt
Matthew J. Sale
Simon J. Cook
Reviews24 Sept 2015
Nature Reviews Cancer

Volume: 15, P: 577-592
Myelosuppression and kinase selectivity of multikinase angiogenesis inhibitors

R Kumar
M-C Crouthamel
A G King
ResearchOpen Access20 Oct 2009
British Journal of Cancer

Volume: 101, P: 1717-1723
Concurrent loss of the PTEN and RB1 tumor suppressors attenuates RAF dependence in melanomas harboring ^V600EBRAF

F Xing
Y Persaud
D B Solit
Research04 Jul 2011
Oncogene

Volume: 31, P: 446-457
CD133⁺ HCC cancer stem cells confer chemoresistance by preferential expression of the Akt/PKB survival pathway

S Ma
T K Lee
X-Y Guan
Research24 Sept 2007
Oncogene

Volume: 27, P: 1749-1758
The ERK1/2 mitogen-activated protein kinase pathway as a master regulator of the G1- to S-phase transition

S Meloche
J Pouysségur
Reviews14 May 2007
Oncogene

Volume: 26, P: 3227-3239
Braf^V600E cooperates with Pten loss to induce metastatic melanoma

Martin McMahon and colleagues have generated a new mouse model of metastatic melanoma by generating mice with an activating mutation of Braf and deletion of Pten. The mice show metastatic melanoma with 100% penetrance and short latency, and should serve as a useful pre-clinical model in which to evaluate new therapies.

David Dankort
David P Curley
Marcus Bosenberg
Research12 Mar 2009
Nature Genetics

Volume: 41, P: 544-552
Integrin αvβ6-associated ERK2 mediates MMP-9 secretion in colon cancer cells

X Gu
J Niu
M V Agrez
ResearchOpen Access23 Jul 2002
British Journal of Cancer

Volume: 87, P: 348-351
Elevated JNK activation contributes to the pathogenesis of human brain tumors

Marc A Antonyak
Lawrence C Kenyon
Albert J Wong
Research29 Jul 2002
Oncogene

Volume: 21, P: 5038-5046
Proteomic identification of secreted proteins as surrogate markers for signal transduction inhibitor activity

C M McClelland
W J Gullick
ResearchOpen Access09 Jan 2007
British Journal of Cancer

Volume: 96, P: 284-289
Radiosensitization and apoptosis

Ruth J Muschel
Daniel E Soto
Eric J Bernhard
Reviews12 Jan 1999
Oncogene

Volume: 17, P: 3359-3363
Differential effects of the poly (ADP-ribose) polymerase (PARP) inhibitor NU1025 on topoisomerase I and II inhibitor cytotoxicity in L1210 cells in vitro

K J Bowman
D R Newell
N J Curtin
ResearchOpen Access03 Jan 2001
British Journal of Cancer

Volume: 84, P: 106-112
KRAS mutational subtype and copy number predict in vitro response of human pancreatic cancer cell lines to MEK inhibition

H Hamidi
M Lu
R S Finn
ResearchOpen Access28 Aug 2014
British Journal of Cancer

Volume: 111, P: 1788-1801
The retinoid anticancer signal: mechanisms of target gene regulation

T Liu
A Bohlken
G M Marshall
ResearchOpen Access12 Jul 2005
British Journal of Cancer

Volume: 93, P: 310-318
The novel tyrosine kinase inhibitor EXEL-0862 induces apoptosis in human FIP1L1-PDGFR-α-expressing cells through caspase-3-mediated cleavage of Mcl-1

J Pan
A Quintás-Cardama
S Verstovsek
Research10 May 2007
Leukemia

Volume: 21, P: 1395-1404
Selective inhibition of choline kinase simultaneously attenuates MAPK and PI3K/AKT signaling

A Yalcin
B Clem
J Chesney
Research26 Oct 2009
Oncogene

Volume: 29, P: 139-149
Control of MAPK signalling: from complexity to what really matters

Jorrit J Hornberg
Bernd Binder
Hans V Westerhoff
Research20 Jun 2005
Oncogene

Volume: 24, P: 5533-5542
Phase I study of FOLFIRI plus pimasertib as second-line treatment for KRAS-mutated metastatic colorectal cancer

T Macarulla
A Cervantes
F Ciardiello
ResearchOpen Access19 May 2015
British Journal of Cancer

Volume: 112, P: 1874-1881
Dual blockade of EGFR and ERK1/2 phosphorylation potentiates growth inhibition of breast cancer cells

D C Lev
L S Kim
J E Price
ResearchOpen Access27 Jul 2004
British Journal of Cancer

Volume: 91, P: 795-802
Variable apoptotic response of NSCLC cells to inhibition of the MEK/ERK pathway by small molecules or dominant negative mutants

J Brognard
P A Dennis
Research16 Aug 2002
Cell Death & Differentiation

Volume: 9, P: 893-904
Upregulation of calcium-sensing receptor and mitogen-activated protein kinase signalling in the regulation of growth and differentiation in colon carcinoma

N Bhagavathula
E A Kelley
J Varani
ResearchOpen Access08 Nov 2005
British Journal of Cancer

Volume: 93, P: 1364-1371
Squalamine and cisplatin block angiogenesis and growth of human ovarian cancer cells with or without HER-2 gene overexpression

Dan Li
Jon I Williams
Richard J Pietras
Research26 Apr 2002
Oncogene

Volume: 21, P: 2805-2814
Effects of ErbB-2 overexpression on mitogenic signalling and cell cycle progression in human breast luminal epithelial cells

John F Timms
Sarah L White
Michael D Waterfield
Research23 Sept 2002
Oncogene

Volume: 21, P: 6573-6586
ERK1/2 and p38 cooperate to induce a p21^CIP1-dependent G₁ cell cycle arrest

Daniel E Todd
Ruth M Densham
Simon J Cook
Research23 Feb 2004
Oncogene

Volume: 23, P: 3284-3295
4-Methylnitrosamino-1-3-pyridyl-1-butanone (NNK) promotes lung cancer cell survival by stimulating thromboxane A₂ and its receptor

R-Y Huang
M-Y Li
G G Chen
Research06 Sept 2010
Oncogene

Volume: 30, P: 106-116
Quantitative single cell determination of ERK phosphorylation and regulation in relapsed and refractory primary acute myeloid leukemia

M R Ricciardi
T McQueen
M Andreeff
Research07 Jul 2005
Leukemia

Volume: 19, P: 1543-1549
Targeted therapy for metastatic renal cell carcinoma

P H Patel
R S K Chaganti
R J Motzer
ReviewsOpen Access07 Feb 2006
British Journal of Cancer

Volume: 94, P: 614-619
Effects of physiological and synthetic IAP antagonism on c-IAP-dependent signaling

A J Kocab
A Veloso
C S Duckett
Research09 Feb 2015
Oncogene

Volume: 34, P: 5472-5481

Search

Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer

CL100 expression is down-regulated in advanced epithelial ovarian cancer and its re-expression decreases its malignant potential

Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia

Direct integrin αvβ6-ERK binding: implications for tumour growth

ERK1/2 is activated in non-small-cell lung cancer and associated with advanced tumours

MEK1 and MEK2 inhibitors and cancer therapy: the long and winding road

Myelosuppression and kinase selectivity of multikinase angiogenesis inhibitors

Concurrent loss of the PTEN and RB1 tumor suppressors attenuates RAF dependence in melanomas harboring ^V600EBRAF

CD133⁺ HCC cancer stem cells confer chemoresistance by preferential expression of the Akt/PKB survival pathway

The ERK1/2 mitogen-activated protein kinase pathway as a master regulator of the G1- to S-phase transition

Braf^V600E cooperates with Pten loss to induce metastatic melanoma

Integrin αvβ6-associated ERK2 mediates MMP-9 secretion in colon cancer cells

Elevated JNK activation contributes to the pathogenesis of human brain tumors

Proteomic identification of secreted proteins as surrogate markers for signal transduction inhibitor activity

Radiosensitization and apoptosis

Differential effects of the poly (ADP-ribose) polymerase (PARP) inhibitor NU1025 on topoisomerase I and II inhibitor cytotoxicity in L1210 cells in vitro

KRAS mutational subtype and copy number predict in vitro response of human pancreatic cancer cell lines to MEK inhibition

The retinoid anticancer signal: mechanisms of target gene regulation

The novel tyrosine kinase inhibitor EXEL-0862 induces apoptosis in human FIP1L1-PDGFR-α-expressing cells through caspase-3-mediated cleavage of Mcl-1

Selective inhibition of choline kinase simultaneously attenuates MAPK and PI3K/AKT signaling

Control of MAPK signalling: from complexity to what really matters

Phase I study of FOLFIRI plus pimasertib as second-line treatment for KRAS-mutated metastatic colorectal cancer

Dual blockade of EGFR and ERK1/2 phosphorylation potentiates growth inhibition of breast cancer cells

Variable apoptotic response of NSCLC cells to inhibition of the MEK/ERK pathway by small molecules or dominant negative mutants

Upregulation of calcium-sensing receptor and mitogen-activated protein kinase signalling in the regulation of growth and differentiation in colon carcinoma

Squalamine and cisplatin block angiogenesis and growth of human ovarian cancer cells with or without HER-2 gene overexpression

Effects of ErbB-2 overexpression on mitogenic signalling and cell cycle progression in human breast luminal epithelial cells

ERK1/2 and p38 cooperate to induce a p21^CIP1-dependent G₁ cell cycle arrest

4-Methylnitrosamino-1-3-pyridyl-1-butanone (NNK) promotes lung cancer cell survival by stimulating thromboxane A₂ and its receptor

Quantitative single cell determination of ERK phosphorylation and regulation in relapsed and refractory primary acute myeloid leukemia

Targeted therapy for metastatic renal cell carcinoma

Effects of physiological and synthetic IAP antagonism on c-IAP-dependent signaling

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