In response to activation of death receptors, a multimeric signalling complex assembles in which FADD binds caspase 8 and FLIP through structurally similar binding surfaces. Majkut et al.show that each surface preferentially binds to one of the two proteins, resulting in the formation of a trimeric intermediate.
- J. Majkut
- M. Sgobba
- D. B. Longley
