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Showing 1–10 of 10 results

Advanced filters: Author: J. Bradley Zuchero Clear advanced filters

Oligodendrocyte calcium signaling promotes actin-dependent myelin sheath extension

The cell biological mechanisms that govern myelin sheath extension remain incompletely understood. Here, the authors find that calcium signaling in oligodendrocytes is required for the actin-dependent extension of myelin sheaths.

Manasi Iyer
Husniye Kantarci
J. Bradley Zuchero
ResearchOpen Access04 Jan 2024
Nature Communications

Volume: 15, P: 1-20
CNS myelination requires VAMP2/3-mediated membrane expansion in oligodendrocytes

Understanding myelination is important for CNS plasticity and disease. Here the authors show exocytosis mediated by the vesicular SNARE proteins VAMP2/3 is involved in oligodendrocyte membrane expansion.

Mable Lam
Koji Takeo
J. Bradley Zuchero
ResearchOpen Access23 Sept 2022
Nature Communications

Volume: 13, P: 1-21
Author Correction: Young CSF restores oligodendrogenesis and memory in aged mice via Fgf17

Tal Iram
Fabian Kern
Tony Wyss-Coray
Amendments and Corrections13 Dec 2022
Nature

Volume: 613, P: E1
Young CSF restores oligodendrogenesis and memory in aged mice via Fgf17

Fgf17 in young CSF boosts oligodendrocyte progenitor cell proliferation and differentiation in the aged hippocampus, improving memory function.

Tal Iram
Fabian Kern
Tony Wyss-Coray
Research11 May 2022
Nature

Volume: 605, P: 509-515
Sex differences in the inflammatory response of the mouse DRG and its connection to pain in experimental autoimmune encephalomyelitis

Aislinn D. Maguire
Timothy N. Friedman
Bradley J. Kerr
ResearchOpen Access05 Dec 2022
Scientific Reports

Volume: 12, P: 1-16
Clonally expanded B cells in multiple sclerosis bind EBV EBNA1 and GlialCAM

The identification of high-affinity molecular mimicry between the Epstein–Barr virus (EBV) transcription factor EBNA1 and the CNS protein GlialCAM provides a mechanistic link between multiple sclerosis and EBV.

Tobias V. Lanz
R. Camille Brewer
William H. Robinson
Research24 Jan 2022
Nature

Volume: 603, P: 321-327
A class of anti-inflammatory lipids decrease with aging in the central nervous system

Tan et al. reveal that a class of lipids, 3-sulfogalactosyl diacylglycerols, decrease in the central nervous system with aging. 3-sulfogalactosyl diacylglycerols are present in the human brain and suppress inflammation suggesting these lipids may play a role in age-related diseases and inflammation.

Dan Tan
Srihari Konduri
Alan Saghatelian
Research20 Oct 2022
Nature Chemical Biology

Volume: 19, P: 187-197
Generation of oligodendroglial cells by direct lineage conversion

Two studies show direct conversion of mouse embryonic fibroblasts to oligodendrocyte progenitor cells capable of generating myelinating oligodendrocytes.

Nan Yang
J Bradley Zuchero
Marius Wernig
Research14 Apr 2013
Nature Biotechnology

Volume: 31, P: 434-439
DeActs: genetically encoded tools for perturbing the actin cytoskeleton in single cells

DeActs are genetically encoded tools that perturb the actin cytoskeleton. In contrast to drugs such as latrunculin, they can be targeted to specific cell types, which is demonstrated in the developing mouse brain and in Caenorhabditis elegans.

Martin Harterink
Marta Esteves da Silva
J Bradley Zuchero
Research10 Apr 2017
Nature Methods

Volume: 14, P: 479-482
p53-cofactor JMY is a multifunctional actin nucleation factor

JMY, originally discovered as a binding partner of the p53 co-activator p300, is an actin-nucleating protein, assembling filaments both by activation of the Arp2/3 complex and through an Arp2/3-independent mechanism.

J. Bradley Zuchero
Amanda S. Coutts
R. Dyche Mullins
Research15 Mar 2009
Nature Cell Biology

Volume: 11, P: 451-459