Peptide nucleic acids (PNAs) can invade canonical nucleic acid dimers but may be limited to certain sequences or perform poorly under physiological conditions. Here PNAs containing Janus bases invade a range of RNA and DNA sequences via Watson-Crick base pairing under near-physiological conditions.
- Shivaji A. Thadke
- V. M. Hridya
- Danith H. Ly