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Showing 1–5 of 5 results
Advanced filters: Author: J. E. Arango-Ossa Clear advanced filters

  • Cancer whole-genome and transcriptome sequencing (cWGTS) has been challenging to implement in clinical settings. Here, the authors develop a workflow to deliver robust cWGTS analyses and reports within clinically-relevant timeframes for paediatric, adolescent and young adult solid tumour patients.

    • N. Shukla
    • M. F. Levine
    • E. Papaemmanuil
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-15

  • Classification and risk-stratification for Acute Myeloid Leukemia (AML) at diagnosis are primarily based on cytogenetics and only a few gene mutations. Here, the authors study the genomic landscape of 3653 AML patients and characterize 16 non-overlapping molecular subgroups of clinical relevance for disease classification and risk prognostication.

    • Yanis Tazi
    • Juan E. Arango-Ossa
    • Elli Papaemmanuil
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-16

  • In multiple myeloma, disease progresses via seeding to different anatomic sites and clonal expansion. Here, utilising autopsy material, the authors show that systemic seeding accelerates at relapse following treatment.

    • Heather J. Landau
    • Venkata Yellapantula
    • Francesco Maura
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-10

  • Environmental exposures shape patterns of selection for mutations in clonal hematopoiesis. Cancer therapies promote the growth of clones with mutations that are strongly enriched in treatment-related myeloid neoplasms.

    • Kelly L. Bolton
    • Ryan N. Ptashkin
    • Elli Papaemmanuil
    Research
    Nature Genetics
    Volume: 52, P: 1219-1226