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Showing 1–2 of 2 results
Advanced filters: Author: J. Geddes Sweeney Clear advanced filters

  • Aberrant glycosylation patterns on cancer cells promote several pro-tumorigenic functions, including enhancing tumor cell proliferation. Here the authors provide data that show melanoma cells downregulate GCNT2 with consequent loss of I-branched glycans; this leads to the formation of extended i-linear glycans and enhances melanoma growth via increases, in part, by IGF-1- and extracellular matrix-induced signaling.

    • Jenna Geddes Sweeney
    • Jennifer Liang
    • Charles J. Dimitroff
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-18

  • Leukocytes are coated with glycans that modulate immune function through interactions with lectins. Here, the authors characterize the N-glycan repertoire of human tonsillar B cells. They report that Gal-9 is an intrinsic regulator of B cell activation that may differentially modulate BCR signaling at steady state and within germinal centers due to expression of I-branched glycans.

    • N. Giovannone
    • J. Liang
    • C. J. Dimitroff
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-17