Chen et al., examined how AFCO₂ laser therapy reduces hypertrophic scars by performing scRNA seq on patient biopsies taken before and after treatment and assessing clinical scar improvement. Earlier scars respond best, with good outcomes linked to regenerative fibroblast recruitment and distinct pro regenerative transcriptional programs, whereas poor responses involve persistent inflammatory and pro fibrotic signalling, highlighting a therapeutic window and potential cellular targets for improving laser based scar treatments.
- Yung-Yi Chen
- Christopher Mahony
- Janet M. Lord
