SET-26, HCF-1, HDA-1 are factors that help package DNA and regulate gene expression. Here, the authors find that SET-26 recruits HCF-1 to specific locations along the genome, where they antagonize the activity of HDA-1. Together, they maintain balanced gene expression and longevity in C. elegans.
- Felicity J. Emerson
- Caitlin Chiu
- Siu Sylvia Lee
