Nature Search

Activation of Smad signaling enhances collagenase-3 (MMP-13) expression and invasion of head and neck squamous carcinoma cells

S-K Leivonen
R Ala-aho
V-M Kähäri
Research09 Jan 2006
Oncogene

Volume: 25, P: 2588-2600
Towards fair decentralized benchmarking of healthcare AI algorithms with the Federated Tumor Segmentation (FeTS) challenge

Federated learning (FL) algorithms have emerged as a promising solution to train models for healthcare imaging across institutions while preserving privacy. Here, the authors describe the Federated Tumor Segmentation (FeTS) challenge for the decentralised benchmarking of FL algorithms and evaluation of Healthcare AI algorithm generalizability in real-world cancer imaging datasets.

Maximilian Zenk
Ujjwal Baid
Spyridon Bakas
ResearchOpen Access08 Jul 2025
Nature Communications

Volume: 16, P: 1-20
Detection of a large mass of dust in a radio galaxy at redshift z = 3.8

James S. Dunlop
David H. Hughes
Martin J. Ward
Research04 Aug 1994
Nature

Volume: 370, P: 347-349
Radiation-induced cell cycle arrest compromised by p21 deficiency

James Brugarolas
Chitra Chandrasekaran
Gregory J. Hannon
Research12 Oct 1995
Nature

Volume: 377, P: 552-557
A WD-domain protein that is associated with and phosphorylated by the type II TGF-β receptor

Ruey-Hwa Chen
Päivi J. Miettinen
Rik Derynck
Research12 Oct 1995
Nature

Volume: 377, P: 548-552
TGF-β-mediated activation of RhoA signalling is required for efficient ^V12HaRas and ^V600EBRAF transformation

Y M Fleming
G J Ferguson
G J Inman
Research15 Dec 2008
Oncogene

Volume: 28, P: 983-993
Federated learning enables big data for rare cancer boundary detection

Federated ML (FL) provides an alternative to train accurate and generalizable ML models, by only sharing numerical model updates. Here, the authors present the largest FL study to-date to generate an automatic tumor boundary detector for glioblastoma.

Sarthak Pati
Ujjwal Baid
Spyridon Bakas
ResearchOpen Access05 Dec 2022
Nature Communications

Volume: 13, P: 1-17
Prospects for the use of amorphous semiconductors in solar energy conversion

J. I. B. Wilson
D. Weaire
Reviews01 Sept 1978
Nature

Volume: 275, P: 93-96
Structures of TGF-β with betaglycan and signaling receptors reveal mechanisms of complex assembly and signaling

Betaglycan is a co-receptor for selective TGF-β family ligands. Here, the authors solve its structure in complex with TGF-β and the signaling receptors, which explains its ligand selectivity and reveals its mechanism in potentiating TGF-β signaling.

Łukasz Wieteska
Alexander B. Taylor
Andrew P. Hinck
ResearchOpen Access26 Feb 2025
Nature Communications

Volume: 16, P: 1-20
Author Correction: MEG3 long noncoding RNA regulates the TGF-β pathway genes through formation of RNA–DNA triplex structures

Tanmoy Mondal
Santhilal Subhash
Chandrasekhar Kanduri
Amendments and CorrectionsOpen Access21 Nov 2019
Nature Communications

Volume: 10, P: 1-2
The transcription factor LHX2 mediates and enhances oncogenic BMP signaling in medulloblastoma

Yae Ohata
Mohamad M. Ali
Aristidis Moustakas
ResearchOpen Access28 Mar 2025
Cell Death & Differentiation

Volume: 32, P: 1915-1929
TGF-β orchestrates fibrogenic and developmental EMTs via the RAS effector RREB1

RAS and TGF-β pathways regulate distinct modes of epithelial-to-mesenchymal transition via RAS-responsive element binding protein 1.

Jie Su
Sophie M. Morgani
Joan Massagué
Research08 Jan 2020
Nature

Volume: 577, P: 566-571
MEG3 long noncoding RNA regulates the TGF-β pathway genes through formation of RNA–DNA triplex structures

Long noncoding RNAs (lncRNAs) regulate gene expression by association with chromatin. Here, the authors show that lncRNA MEG3regulates the TGF-β pathway by bridging the interactions between polycomb repressive complex 2 and the distal regulatory elements of the TGF-β pathway genes via formation of RNA–DNA triplexes.

Tanmoy Mondal
Santhilal Subhash
Chandrasekhar Kanduri
ResearchOpen Access24 Jul 2015
Nature Communications

Volume: 6, P: 1-17
TRAF6 ubiquitinates TGFβ type I receptor to promote its cleavage and nuclear translocation in cancer

TGFβ can function as both a tumour suppressor and tumour promoter under different cellular contexts. Here, the cleavage product of the TGFβ type I receptor is shown to be generated in a TGFβ-dependent manner, and can induce the expression of genes involved in tumour cell invasion.

Yabing Mu
Reshma Sundar
Marene Landström
ResearchOpen Access31 May 2011
Nature Communications

Volume: 2, P: 1-11
Hyperactivation of Stat3 in gp130 mutant mice promotes gastric hyperproliferation and desensitizes TGF-β signaling

Brendan J Jenkins
Dianne Grail
Matthias Ernst
Research24 Jul 2005
Nature Medicine

Volume: 11, P: 845-852
miR-367 promotes epithelial-to-mesenchymal transition and invasion of pancreatic ductal adenocarcinoma cells by targeting the Smad7-TGF-β signalling pathway

Z Zhu
Y Xu
P Wang
ResearchOpen Access17 Mar 2015
British Journal of Cancer

Volume: 112, P: 1367-1375
Tumor suppressor Fbxw7 regulates TGFβ signaling by targeting TGIF1 for degradation

M T Bengoechea-Alonso
J Ericsson
Research12 Jul 2010
Oncogene

Volume: 29, P: 5322-5328
Stellar feedback as the origin of an extended molecular outflow in a starburst galaxy

A high-velocity outflow of molecular gas from a starburst galaxy has been observed to extend about ten kiloparsecs; its velocity is consistent with the momentum flux from stellar radiation pressure, showing that bursts of star formation can eject large amounts of cold gas from the central regions of galaxies, curtailing star formation.

J. E. Geach
R. C. Hickox
J. Moustakas
Research03 Dec 2014
Nature

Volume: 516, P: 68-70
Suv39h histone methyltransferases interact with Smads and cooperate in BMP-induced repression

Pilar Frontelo
Jennifer E Leader
Robert J Lechleider
Research26 Apr 2004
Oncogene

Volume: 23, P: 5242-5251
Stabilization of phenotypic plasticity through mesenchymal-specific DNA hypermethylation in cancer cells

Y Kurasawa
K Kozaki
J Inazawa
Research29 Aug 2011
Oncogene

Volume: 31, P: 1963-1974
Transforming growth factor-β-induced epithelial–mesenchymal transition facilitates epidermal growth factor-dependent breast cancer progression

M K Wendt
J A Smith
W P Schiemann
Research30 Aug 2010
Oncogene

Volume: 29, P: 6485-6498
Endoglin expression in breast tumor cells suppresses invasion and metastasis and correlates with improved clinical outcome

L A Henry
D A Johnson
C M Isacke
Research01 Nov 2010
Oncogene

Volume: 30, P: 1046-1058
Smad7 is inactivated through a direct physical interaction with the LIM protein Hic-5/ARA55

H Wang
K Song
D Danielpour
Research01 Sept 2008
Oncogene

Volume: 27, P: 6791-6805
Unexpected changes in community size structure in a natural warming experiment

A warmer climate is generally expected to favour smaller organisms and steeper body-mass–abundance scaling through food webs. Results from across a stream temperature gradient now show that this effect can be offset by increasing nutrient supply.

Eoin J. O’Gorman
Lei Zhao
Guy Woodward
Research21 Aug 2017
Nature Climate Change

Volume: 7, P: 659-663
Author Correction: Federated learning enables big data for rare cancer boundary detection

Sarthak Pati
Ujjwal Baid
Spyridon Bakas
Amendments and CorrectionsOpen Access26 Jan 2023
Nature Communications

Volume: 14, P: 1-2
Poly(ADP-ribose)-dependent regulation of Snail1 protein stability

M I Rodríguez
A González-Flores
F J Oliver
Research16 May 2011
Oncogene

Volume: 30, P: 4365-4372
TGF-β signaling in T cells: roles in lymphoid and epithelial neoplasia

John J Letterio
Reviews29 Aug 2005
Oncogene

Volume: 24, P: 5701-5712
Transforming Growth Factor-β2 protects the small intestine during methotrexate treatment in rats possibly by reducing stem cell cycling

B van't Land
H P Meijer
M Hoijer
ResearchOpen Access25 Jun 2002
British Journal of Cancer

Volume: 87, P: 113-118
Development of Expression Vectors for Transgenic Fish

Zhanjiang Liu
Boaz Moav
Perry B. Hackett
Research01 Dec 1990
Bio/Technology

Volume: 8, P: 1268-1272
Ultraviolet B Light Emitting Diodes (LEDs) Are More Efficient and Effective in Producing Vitamin D₃ in Human Skin Compared to Natural Sunlight

T. A. Kalajian
A. Aldoukhi
M. F. Holick
ResearchOpen Access13 Sept 2017
Scientific Reports

Volume: 7, P: 1-8
SRF is a nuclear repressor of Smad3-mediated TGF-β signaling

H-J Lee
C-H Yun
S-J Kim
Research03 Jul 2006
Oncogene

Volume: 26, P: 173-185
Fucosylated TGF-β receptors transduces a signal for epithelial–mesenchymal transition in colorectal cancer cells

M Hirakawa
R Takimoto
J Kato
ResearchOpen Access19 Nov 2013
British Journal of Cancer

Volume: 110, P: 156-163
Loss of TGF-β signaling and PTEN promotes head and neck squamous cell carcinoma through cellular senescence evasion and cancer-related inflammation

Y Bian
B Hall
A B Kulkarni
Research31 Oct 2011
Oncogene

Volume: 31, P: 3322-3332
hSSB1 binds and protects p21 from ubiquitin-mediated degradation and positively correlates with p21 in human hepatocellular carcinomas

S Xu
Z Feng
T Kang
Research17 Jan 2011
Oncogene

Volume: 30, P: 2219-2229
TGF-β-induced IRAK-M expression in tumor-associated macrophages regulates lung tumor growth

T J Standiford
R Kuick
V G Keshamouni
Research31 Jan 2011
Oncogene

Volume: 30, P: 2475-2484
Loss of breast epithelial marker hCLCA2 promotes epithelial-to-mesenchymal transition and indicates higher risk of metastasis

V Walia
Y Yu
R C Elble
Research12 Sept 2011
Oncogene

Volume: 31, P: 2237-2246
Molecular characterisation of side population cells with cancer stem cell-like characteristics in small-cell lung cancer

C D Salcido
A Larochelle
L Varticovski
ResearchOpen Access27 Apr 2010
British Journal of Cancer

Volume: 102, P: 1636-1644
A non-Smad mechanism of fibroblast activation by transforming growth factor-β via c-Abl and Egr-1: selective modulation by imatinib mesylate

S Bhattacharyya
W Ishida
J Varga
Research19 Jan 2009
Oncogene

Volume: 28, P: 1285-1297
Transforming growth factor-β1 is the predominant isoform required for breast cancer cell outgrowth in bone

A A Mourskaia
Z Dong
P M Siegel
Research15 Dec 2008
Oncogene

Volume: 28, P: 1005-1015
Extracellular matrix-induced transforming growth factor-β receptor signaling dynamics

N Garamszegi
S P Garamszegi
S P Scully
Research25 Jan 2010
Oncogene

Volume: 29, P: 2368-2380
Deubiquitinases in cancer: new functions and therapeutic options

J M Fraile
V Quesada
C López-Otín
Reviews26 Sept 2011
Oncogene

Volume: 31, P: 2373-2388
TGFβ signaling in head and neck squamous cell carcinoma

R A White
S P Malkoski
X-J Wang
Reviews02 Aug 2010
Oncogene

Volume: 29, P: 5437-5446
Cellular heterogeneity in pancreatic cancer: the different faces of gremlin action

Aristidis Moustakas
J. Matthias Löhr
Rainer L. Heuchel
Research HighlightsOpen Access12 Oct 2022
Signal Transduction and Targeted Therapy

Volume: 7, P: 1-3
Myc represses differentiation-induced p21CIP1 expression via Miz-1-dependent interaction with the p21 core promoter

Siqin Wu
Cihan Cetinkaya
Lars-Gunnar Larsson
Research22 Jan 2003
Oncogene

Volume: 22, P: 351-360

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