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Showing 1–8 of 8 results
Advanced filters: Author: J. Thomas Hannich Clear advanced filters

  • Anoxia─lack of oxygen─commonly occurs during ischaemic heart disease. Using yeast, worms and mice, Hannich et al. show that anoxia-associated tissue injury and cell death are due to accumulation of a non-canonical sphingolipid, 1-deoxydihydroceramide, that damages the cytoskeleton.

    • J. Thomas Hannich
    • A. Galih Haribowo
    • Howard Riezman
    Research
    Nature Metabolism
    Volume: 1, P: 996-1008

  • Targeted protein degradation uses small molecules to recruit proteins to E3 ligases to induce their ubiquitylation and degradation, but only a few human E3 ligases are amenable to this strategy. Here, the authors identify and characterize SP3N, a specific degrader of the prolyl isomerase FKBP12, containing an FKBP12 ligand appended with a flexible alkylamine tail that is metabolized to an active aldehyde species which recruits the SCFFBXO22 ligase for FKBP12 degradation.

    • Chrysanthi Kagiou
    • Jose A. Cisneros
    • Georg E. Winter
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-14

  • SMNDC1 is a splicing factor that binds arginine methylation with its Tudor domain. Here, the authors study the protein’s phase-separating behavior and develop small-molecule Tudor domain inhibitors that perturb SMNDC1 function.

    • Lennart Enders
    • Marton Siklos
    • Stefan Kubicek
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-19

  • Human mutations in PCYT2 result in severe pathology with failure to thrive and progressive degenerative disease. Cikes et al. demonstrate that loss of PCYT2-synthesized phosphatidylethanolamines in muscle impairs sarcolemmal lipid bilayer stability and mitochondrial homeostasis, leading to muscle degeneration and premature ageing in mice.

    • Domagoj Cikes
    • Kareem Elsayad
    • Josef M. Penninger
    Research
    Nature Metabolism
    Volume: 5, P: 495-515

  • Cellular cholesterol levels are tightly regulated. Here, the authors show that the hedgehog signalling receptor PTCH is a cholesterol transporter. Reduction in PTCH activity leads to cellular cholesterol accumulation, changes in nuclear hormone receptor activity and fatty acid metabolism.

    • Carla E. Cadena del Castillo
    • J. Thomas Hannich
    • Anne Spang
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-13