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Showing 1–5 of 5 results
Advanced filters: Author: Jaba Mitra Clear advanced filters

  • Analyses of hippocampal AMPA receptor–auxiliary subunit complexes provide insights into the predominant assemblies and organization of the AMPA receptor, TARP-γ8 and CNIH2/SynDIG4 and explain the mechanism of inhibition of a clinically relevant, brain-region-specific allosteric inhibitor.

    • Jie Yu
    • Prashant Rao
    • Eric Gouaux
    Research
    Nature
    Volume: 594, P: 448-453

  • Light-up aptamers are widely used for fluorescence visualization of non-coding RNA in vivo. Here the authors employ single-molecule fluorescence-force spectroscopy to characterize the mechanical responses of the G-Quadruplex based light-up aptamers Spinach2, iMangoIII and MangoIV, which is of interest for the development of improved fluorogenic modules for imaging applications.

    • Jaba Mitra
    • Taekjip Ha
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-10

  • Signaling via the mTOR complex 1 (mTORC1) maintains cellular and organismal homeostasis. Here the authors show that the AAA + ATPase Thorase binds mTOR to promote disassembly and inactivation of mTORC1 to fine tune TOR signaling according to amino acid availability.

    • George K. E. Umanah
    • Leire Abalde-Atristain
    • Valina L. Dawson
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-18