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Showing 1–13 of 13 results
Advanced filters: Author: Jacinta D. Lucero Clear advanced filters

  • Single-cell DNA methylome profiling allows the study of epigenomic heterogeneity in tissues but has been impeded by library quality. Here the authors demonstrate snmC-seq2 which improves mapping, throughput and library complexity.

    • Chongyuan Luo
    • Angeline Rivkin
    • Joseph R. Ecker
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-6

  • Methylome-based clustering and cross-modality integration with companion datasets from the BRAIN Initiative Cell Census Network enabled the construction of a 3D multi-omic genome atlas of the adult mouse brain featuring thousands of cell-type-specific profiles.

    • Hanqing Liu
    • Qiurui Zeng
    • Joseph R. Ecker
    ResearchOpen Access
    Nature
    Volume: 624, P: 366-377

  • Primary immunodeficiency can predispose patients to mycobacterial disease. Casanova and colleagues identify novel human mutations in the enzyme SPPL2A that result in selective accumulation of CD74 in a dendritic cell subset and lead to their death and the failure to mount effective TH1 responses.

    • Xiao-Fei Kong
    • Ruben Martinez-Barricarte
    • Jean-Laurent Casanova
    Research
    Nature Immunology
    Volume: 19, P: 973-985

  • An atlas of candidate cis-regulatory DNA elements (cCREs) in the adult mouse brain unravels the transcriptional regulatory programs that drive the heterogeneity and complexity of brain structure and function.

    • Songpeng Zu
    • Yang Eric Li
    • Bing Ren
    ResearchOpen Access
    Nature
    Volume: 624, P: 378-389

  • Single cell analysis of transposase-accessible chromatin is deepening our understanding on the origins of cellular diversity, yet methods are limited by data sparsity. Here, the authors introduce SnapATAC, a pipeline to resolve cellular heterogeneity and reveal candidate regulatory elements across different cell populations.

    • Rongxin Fang
    • Sebastian Preissl
    • Bing Ren
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-15

  • An examination of motor cortex in humans, marmosets and mice reveals a generally conserved cellular makeup that is likely to extend to many mammalian species, but also differences in gene expression, DNA methylation and chromatin state that lead to species-dependent specializations.

    • Trygve E. Bakken
    • Nikolas L. Jorstad
    • Ed S. Lein
    ResearchOpen Access
    Nature
    Volume: 598, P: 111-119

  • A comprehensive survey of the epigenome from 45 regions of the mouse cortex, hippocampus, striatum, pallidum and olfactory areas using single-nucleus DNA methylation sequencing enables identification of 161 cell clusters with distinct locations and projection targets and provides insights into the regulatory landscape underlying neuronal diversity and spatial regulation.

    • Hanqing Liu
    • Jingtian Zhou
    • Joseph R. Ecker
    ResearchOpen Access
    Nature
    Volume: 598, P: 120-128

  • The BRAIN Initiative Cell Census Network has constructed a multimodal cell census and atlas of the mammalian primary motor cortex in a landmark effort towards understanding brain cell-type diversity, neural circuit organization and brain function.

    • Edward M. Callaway
    • Hong-Wei Dong
    • Susan Sunkin
    ResearchOpen Access
    Nature
    Volume: 598, P: 86-102

  • Paired-seq allows parallel analysis of transcriptome and accessible chromatin in millions of single cells and can be used to study dynamic and cell-type-specific gene regulatory programs in complex tissues, as demonstrated here for mouse adult cerebral cortex and fetal forebrain.

    • Chenxu Zhu
    • Miao Yu
    • Bing Ren
    Research
    Nature Structural & Molecular Biology
    Volume: 26, P: 1063-1070