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Showing 1–3 of 3 results
Advanced filters: Author: Jack A. Terrett Clear advanced filters

  • Aryl aminooxetanes are used as amide bioisosteres in drug discovery but there are limited strategies for synthesizing them. Now, an approach has been developed that simplifies the synthesis of these privileged motifs, enabling a broad range of amines to be used.

    • Malcolm P. Huestis
    • Jack A. Terrett
    News & Views
    Nature Chemistry
    Volume: 14, P: 120-121

  • Despite advances in carbon–carbon fragment couplings, the ability to forge carbon–oxygen bonds in a general fashion via nickel catalysis has been largely unsuccessful; here, visible-light-excited photoredox catalysts are shown to provide transient access to Ni(iii) species that readily participate in reductive elimination, leading to carbon–oxygen coupling.

    • Jack A. Terrett
    • James D. Cuthbertson
    • David W. C. MacMillan
    Research
    Nature
    Volume: 524, P: 330-334