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The yeast global transcriptional co-repressor protein Cyc8 can propagate as a prion

The transcriptional activator SWI was recently shown to propagate as a prion in yeast. Cyc8, a co-repressor that regulates a similar set of genes as SWI, also propagates as a prion, suggesting a link between chromatin remodelling and cytoplasmic inheritance of prion traits.

Basant K. Patel
Jackie Gavin-Smyth
Susan W. Liebman
Research15 Feb 2009
Nature Cell Biology

Volume: 11, P: 344-349
Obesity induces PD-1 on macrophages to suppress anti-tumour immunity

A study demonstrates that metabolic signalling and inflammatory cues associated with obesity selectively induce expression of PD-1 on tumour-associated macrophages to suppress anti-tumour immunity.

Jackie E. Bader
Melissa M. Wolf
Jeffrey C. Rathmell
Research12 Jun 2024
Nature

Volume: 630, P: 968-975
Structural basis of TMPRSS11D specificity and autocleavage activation

Human proteases TMPRSS2 and TMPRSS11D can be highjacked to mediate cell entry of respiratory viruses. This study examines the biochemical and structural basis of TMPRSS11D auto-activation and substrate specificity, informing peptidomimetic inhibitor development.

Bryan J. Fraser
Ryan P. Wilson
Cheryl H. Arrowsmith
ResearchOpen Access10 May 2025
Nature Communications

Volume: 16, P: 1-13
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Disruption of hmgA by DNA Duplication is Responsible for Hyperpigmentation in a Vibrio anguillarum Strain

Veronica Batallones
Jennifer Fernandez
Marcelo E. Tolmasky
ResearchOpen Access10 Oct 2019
Scientific Reports

Volume: 9, P: 1-10