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Showing 1–3 of 3 results
Advanced filters: Author: Jackie Norrie Clear advanced filters

  • Super-enhancers are regions of genomic DNA comprised of multiple putative enhancers that contribute to dynamic gene expression patterns during development. Here the authors identify a modular super-enhancer in murine retinal development and show that distinct modules are responsible for retinal progenitor cell proliferation during early and bipolar neuron genesis during late retinal development.

    • Victoria Honnell
    • Jackie L. Norrie
    • Michael A. Dyer
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-13

  • Retinoblastoma is a heritable pediatric cancer driven by mutations in RB1. Here, the authors demonstrate the first patient derived model of retinoblastoma using iPSCs from patients with germline mutations in RB1.

    • Jackie L. Norrie
    • Anjana Nityanandam
    • Michael A. Dyer
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-13

  • In most cancers, mutations that lead to oncogene activation and tumor suppressor inactivation synergize to promote tumorigenesis. However, in neuroblastomas, MYCN amplification and ATRX mutations are mutually exclusive and incompatible.

    • Maged Zeineldin
    • Sara Federico
    • Michael A. Dyer
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-20