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Showing 1–21 of 21 results
Advanced filters: Author: Jacob Beal Clear advanced filters

  • Engineering of small-molecule-responsive RNA-binding proteins enables chemical regulation of modified mRNA or RNA replicon expression within mammalian cells for applications in synthetic circuit design and RNA-centered therapeutics.

    • Tyler E. Wagner
    • Jacob R. Becraft
    • Ron Weiss
    Research
    Nature Chemical Biology
    Volume: 14, P: 1043-1050

  • Synthetic biology principles are often used to design circuits that tune gene expression in response to changes in intracellular environments. Here the authors design a modular platform for intracellular protein sensing devices with transcriptional output.

    • Velia Siciliano
    • Breanna DiAndreth
    • Ron Weiss
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-7

  • Public antibody clonotypes that recognize SARS-CoV-2 spike protein are important for protection against COVID-19. Here, the authors characterize sequence motifs in the heavy chain complementarity-determining region (CDR) H3s of two public clonotypes and their association with light chain identity.

    • Timothy J. C. Tan
    • Meng Yuan
    • Nicholas C. Wu
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-10

  • The availability of high performance recombinases with low basal activity and high dynamic range is limited. Here the authors present a library of over 20 orthogonal split recombinases that can be induced by small molecules, light and temperature in vivo.

    • Benjamin H. Weinberg
    • Jang Hwan Cho
    • Wilson W. Wong
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-10

  • Kiwimagi & Letendre et al. present a workflow to quantitatively define recombinase-based digitizer and predict responses to different input signals. With a mechanistic/phenotypic model that can predict circuit performance, they generate a synthetic cell-cell communication device that amplifies a synNotch output signal.

    • Katherine A. Kiwimagi
    • Justin H. Letendre
    • Ron Weiss
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-12

  • This report from the 1000 Genomes Project describes the genomes of 1,092 individuals from 14 human populations, providing a resource for common and low-frequency variant analysis in individuals from diverse populations; hundreds of rare non-coding variants at conserved sites, such as motif-disrupting changes in transcription-factor-binding sites, can be found in each individual.

    • Gil A. McVean
    • David M. Altshuler (Co-Chair)
    • Gil A. McVean
    ResearchOpen Access
    Nature
    Volume: 491, P: 56-65

  • Data on the nutrient content of almost 3,000 aquatic animal-source foods is combined with a food-systems model to show that an increase in aquatic-food production could reduce the inadequate intake of most nutrients.

    • Christopher D. Golden
    • J. Zachary Koehn
    • Shakuntala H. Thilsted
    Research
    Nature
    Volume: 598, P: 315-320

  • Using data gathered from the microphones of the Perseverance rover, the first characterization of the acoustic environment on Mars is presented, showing two distinct values for the speed of sound in CO2-dominated atmosphere.

    • S. Maurice
    • B. Chide
    • P. Willis
    ResearchOpen Access
    Nature
    Volume: 605, P: 653-658

  • 1000 Genomes imputation can increase the power of genome-wide association studies to detect genetic variants associated with human traits and diseases. Here, the authors develop a method to integrate and analyse low-coverage sequence data and SNP array data, and show that it improves imputation performance.

    • Olivier Delaneau
    • Jonathan Marchini
    • Leena Peltonenz
    Research
    Nature Communications
    Volume: 5, P: 1-9

  • The length of a single guide RNA (gRNA) determines the function of Cas9. In this study 20-nt gRNAs allowed nuclease activity and genome editing, whereas 14-nt gRNAs mediated transcriptional activation or repression.

    • Samira Kiani
    • Alejandro Chavez
    • George Church
    Research
    Nature Methods
    Volume: 12, P: 1051-1054

  • Genome-scale engineering requires the integration of a wide range of in silico and in vivo technologies, as well data management procedures and legal infrastructure. Here the authors provide a list of recommendations to address these challenges.

    • Bryan A. Bartley
    • Jacob Beal
    • Elizabeth A. Strychalski
    ReviewsOpen Access
    Nature Communications
    Volume: 11, P: 1-9

  • Results for the final phase of the 1000 Genomes Project are presented including whole-genome sequencing, targeted exome sequencing, and genotyping on high-density SNP arrays for 2,504 individuals across 26 populations, providing a global reference data set to support biomedical genetics.

    • Adam Auton
    • Gonçalo R. Abecasis
    • Gonçalo R. Abecasis
    ResearchOpen Access
    Nature
    Volume: 526, P: 68-74

  • In an inter-laboratory study, the authors compare the accuracy and performance of three optical density calibration protocols (colloidal silica, serial dilution of silica microspheres, and colony-forming unit (CFU) assay). They demonstrate that serial dilution of silica microspheres is the best of these tested protocols, allowing precise and robust calibration that is easily assessed for quality control and can also evaluate the effective linear range of an instrument.

    • Jacob Beal
    • Natalie G. Farny
    • Jiajie Zhou
    ResearchOpen Access
    Communications Biology
    Volume: 3, P: 1-29

  • Walsh et al. examine how dementia impacts daily life and well-being over three years by tracking changes in behaviour, memory, and daily activities, for people with dementia and their carers. They find that as cognitive decline progresses, daily challenges increase, affecting carer stress and the use of community services.

    • Chloe Walsh
    • Alexander Capstick
    • Payam Barnaghi
    ResearchOpen Access
    Communications Medicine
    Volume: 5, P: 1-13