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Showing 1–2 of 2 results
Advanced filters: Author: Jacob Hirdler Clear advanced filters

  • Tumor-derived soluble PD-L1 drives immune checkpoint inhibitor (ICI) resistance and has recently been reported to be removed by therapeutic plasma exchange (TPE). Here, the authors report a phase I clinical trial investigating the combination of radiotherapy, TPE, and ICI rechallenge in patients with ICI-refractory metastatic melanoma with high PD-L1.

    • Jacob J. Orme
    • Henan Zhang
    • Sean S. Park
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-11

  • Although effector activity and memory formation in CD8 + T cells are known to depend on mTORC1-mediated metabolic regulation, the molecular mechanisms involved are lesser known. Here authors show that NKG7, a lysosomal protein specifically expressed in CD8 + T cells, inhibits mTORC1 function via the lysosomal proton pump, vacuolar ATPase, promoting antitumor activity and expansion of memory T cell precursors.

    • Hyoungjun Ham
    • Jacob B. Hirdler
    • Daniel D. Billadeau
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-21