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Showing 1–8 of 8 results
Advanced filters: Author: Jacob Househam Clear advanced filters

  • A study maps genetic and epigenetic heterogeneity of primary colorectal adenomas and cancers at single-clone resolution through spatial multi-omic profiling of individual glands and adjacent normal tissue.

    • Timon Heide
    • Jacob Househam
    • Andrea Sottoriva
    ResearchOpen Access
    Nature
    Volume: 611, P: 733-743

  • Intratumour genetic ancestry only infrequently affects gene expression traits and subclonal evolution in colorectal cancer, with most genetic intratumour variation having no detected phenotypic consequence and transcriptional plasticity being widespread within a tumour.

    • Jacob Househam
    • Timon Heide
    • Trevor A. Graham
    ResearchOpen Access
    Nature
    Volume: 611, P: 744-753

  • Whole-genome sequencing of more than 2,000 colorectal carcinoma samples provides a highly detailed view of the genomic landscape of this cancer and identifies new driver mutations.

    • Alex J. Cornish
    • Andreas J. Gruber
    • Richard S. Houlston
    ResearchOpen Access
    Nature
    Volume: 633, P: 127-136

  • Mathematical modeling of evolutionary dynamics of neoantigens and immune escape in growing tumors shows that strong negative selection for neoantigens inhibits tumor growth but also provides a strong selective pressure for the evolution of immune escape.

    • Eszter Lakatos
    • Marc J. Williams
    • Trevor A. Graham
    Research
    Nature Genetics
    Volume: 52, P: 1057-1066