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Showing 1–4 of 4 results

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A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
DNA-delivered antibody cocktail exhibits improved pharmacokinetics and confers prophylactic protection against SARS-CoV-2

Here, Parzych et al describe the development of a DNA-delivered SARS-CoV-2 mAb cocktail displaying synergistic RBD binding that confers broad neutralizing activity against variants of concern and prophylactic efficacy in multiple small animal models.

Elizabeth M. Parzych
Jianqiu Du
David B. Weiner
ResearchOpen Access06 Oct 2022
Nature Communications

Volume: 13, P: 1-16
Sestrin is a key regulator of stem cell function and lifespan in response to dietary amino acids

The authors identify the evolutionarily conserved amino acid-sensing protein Sestrin as a key mediator of dietary restriction benefits in flies. Sestrin regulates gut stem cell activity via the TOR pathway, resulting in improved gut health and longevity.

Jiongming Lu
Ulrike Temp
Linda Partridge
Research23 Nov 2020
Nature Aging

Volume: 1, P: 60-72
Epidemiology of 7375 children and adolescents hospitalized with COVID-19 in Germany, reported via a prospective, nationwide surveillance study in 2020–2022

Maren Doenhardt
Markus Hufnagel
Ulrich Zügge
ResearchOpen Access02 Jan 2024
Scientific Reports

Volume: 14, P: 1-15