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VAMP7 controls T cell activation by regulating the recruitment and phosphorylation of vesicular Lat at TCR-activation sites

How the adaptor Lat and the TCR come together after TCR triggering is not well understood. Hivroz and colleagues show that the vesicular protein VAMP7 is required for the recruitment of Lat-containing vesicles to TCR-activation sites.

Paola Larghi
David J Williamson
Claire Hivroz
Research12 May 2013
Nature Immunology

Volume: 14, P: 723-731
Cystine–glutamate antiporter deletion accelerates motor recovery and improves histological outcomes following spinal cord injury in mice

Lindsay Sprimont
Pauline Janssen
Charles Nicaise
ResearchOpen Access09 Jun 2021
Scientific Reports

Volume: 11, P: 1-15
Endophilin-A2 functions in membrane scission in clathrin-independent endocytosis

Endophilin-A2 (endoA2) is shown to mediate clathrin-independent endocytosis of Shiga and cholera toxins, and to function in parallel with dynamin and actin in the pulling-force-driven scission of Shiga-toxin-induced tubular structures.

Henri-François Renard
Mijo Simunovic
Ludger Johannes
Research17 Dec 2014
Nature

Volume: 517, P: 493-496