Nature Search

Erratum: Low-density lipoprotein protects Vibrio vulnificus-induced lethality through blocking lipopolysaccharide action

Kwang-Hyun Park
Jong-Suk Kim
Myung-Kwan Han
Amendments and CorrectionsOpen Access01 Dec 2007
Experimental & Molecular Medicine

Volume: 39, P: 839
Low-density lipoprotein protects Vibrio vulnificus-induced lethality through blocking lipopolysaccharide action

Kwang-Hyun Park
Jong-Suk Kim
Myung-Kwan Han
ResearchOpen Access01 Oct 2007
Experimental & Molecular Medicine

Volume: 39, P: 673-678
Characterization of aberrant FHIT transcripts in gastric adenocarcinomas

Sang-Han Lee
Chang-Jin Kim
Moon-Soo Lee
ResearchOpen Access01 Sept 2001
Experimental & Molecular Medicine

Volume: 33, P: 124-130
Lysophosphatidylcholine suppresses apoptosis and induces neurite outgrowth in PC12 cells through activation of phospholipase D2

Doo Hee Yun
Eun Su Jeon
Jae Ho Kim
ResearchOpen Access01 Aug 2006
Experimental & Molecular Medicine

Volume: 38, P: 375-384
Therapeutic effects of lysophosphatidylcholine in experimental sepsis

Ji-Jing Yan
Jun-Sub Jung
Dong-Keun Song
Research11 Jan 2004
Nature Medicine

Volume: 10, P: 161-167
Proteomics-based functional studies reveal that galectin-3 plays a protective role in the pathogenesis of intestinal Behçet’s disease

Hyun Jung Lee
Jae Hyeon Kim
Jae Hee Cheon
ResearchOpen Access12 Aug 2019
Scientific Reports

Volume: 9, P: 1-13
HDL-bound S1P affects the subventricular niche and early neuropathological features of Alzheimer’s disease

The blood ApoM-S1P complex regulates vascular functions, but its role in neurogenic niches remains unclear. Here, the authors show that the blood ApoM-S1P complex preserves V-SVZ homeostasis and protects against early features of Alzheimer’s disease.

Byung Jo Choi
Ju Yeon Hong
Hee Kyung Jin
ResearchOpen Access01 Jul 2025
Nature Communications

Volume: 16, P: 1-22
Distinctive CD39⁺CD9⁺ lung interstitial macrophages suppress IL-23/Th17-mediated neutrophilic asthma by inhibiting NETosis

Interstitial macrophages (IM) are a specialised population of macrophage cells in the lungs which regulate lung inflammation. Here using mouse models, the authors show that a CD39⁺CD9⁺ IM population reduce IL-23/Th17 driven neutrophilic inflammation through suppression of NETosis.

Seunghan Han
Bomin Kim
Ji-Hwan Ryu
ResearchOpen Access04 Oct 2024
Nature Communications

Volume: 15, P: 1-18
Long-term physical exercise facilitates putative glymphatic and meningeal lymphatic vessel flow in humans

This study shows that long-term exercise improves brain waste clearance by enhancing glymphatic influx and mLV flow through neuroinflammation reduction, highlighting exercise as a promising non-drug strategy to prevent neurodegenerative diseases.

Roh-Eul Yoo
Jun-Hee Kim
Seung Hong Choi
ResearchOpen Access09 Apr 2025
Nature Communications

Volume: 16, P: 1-10
Long-term outcomes according to additional treatments after endoscopic resection for rectal small neuroendocrine tumors

Jae Hwang Cha
Da Hyun Jung
Hyun Jung Lee
ResearchOpen Access20 Mar 2019
Scientific Reports

Volume: 9, P: 1-8
TRIM40 is a pathogenic driver of inflammatory bowel disease subverting intestinal barrier integrity

The cortical actin cytoskeleton plays a role in maintaining intestinal epithelial integrity. Here the authors report that TRIM40, an E3 ligase, disrupts cortical actin formation and leads to loss of epithelial barrier integrity, and that genetic loss of TRIM40 is protective against experimental colitis in male mice.

Sujin Kang
Jaekyung Kim
Boyoun Park
ResearchOpen Access09 Feb 2023
Nature Communications

Volume: 14, P: 1-14
Publisher Correction: Effects of metformin on colorectal cancer stem cells depend on alterations in glutamine metabolism

Jae Hyun Kim
Kyoung Jin Lee
Tae Il Kim
Amendments and CorrectionsOpen Access28 Aug 2018
Scientific Reports

Volume: 8, P: 1
Plasma GFAP as a mediator and moderator of Aβ, tau, and neurodegeneration in Alzheimer’s disease

Jun Sung Kim
Dahyun Yi
Hyeong Gon Yu
ResearchOpen Access09 Jan 2026
npj Dementia

Volume: 2, P: 1-8
Immunotherapy targeting plasma ASM is protective in a mouse model of Alzheimer’s disease

Acid sphingomyelinase (ASM) is a sphingolipid metabolizing enzyme that catalyzes the hydrolysis of sphingomyelin to ceramide, and previous work has shown it is upregulated in models of Alzheimer’s disease. Here the authors demonstrate in a mouse model of Alzheimer’s disease that antibody-based immunotherapy targeting plasma ASM resulted in attenuated neuropathological features by suppressing pathogenic Th17 cells.

Byung Jo Choi
Min Hee Park
Jae-sung Bae
ResearchOpen Access24 Mar 2023
Nature Communications

Volume: 14, P: 1-17
Genomics yields biological and phenotypic insights into bipolar disorder

Using multi-ancestry genome-wide association study and fine-mapping, 298 loci and 36 credible genes are identified in the aetiology of bipolar disorder.

Kevin S. O’Connell
Maria Koromina
Dan Siskind
Research22 Jan 2025
Nature

Volume: 639, P: 968-975
MG53-induced IRS-1 ubiquitination negatively regulates skeletal myogenesis and insulin signalling

The protein MG53 is known to inhibit myogenesis. Here, Ko et al. show that MG53 is an E3 ubiquitin ligase that mediates degradation of insulin receptor substrate 1 in skeletal muscle, thereby regulating myogenesis and insulin sensitivity in vitro and in vivo.

Jae-Sung Yi
Jun Sub Park
Young-Gyu Ko
Research22 Aug 2013
Nature Communications

Volume: 4, P: 1-12
N-AS-triggered SPMs are direct regulators of microglia in a model of Alzheimer’s disease

Neuronal sphingosine kinase 1 (SphK1) acetylates COX2 which is needed for microglial phagocytosis activity, and release of pro-resolving mediators (SPMs) from neurons. Here the authors examine how SphK1-mediates COX2 acetylation, and how this leads to increased secretion of SPMs from neurons in the context of Alzheimer’s disease models.

Ju Youn Lee
Seung Hoon Han
Jae-sung Bae
ResearchOpen Access12 May 2020
Nature Communications

Volume: 11, P: 1-19
Flat-surface-assisted and self-regulated oxidation resistance of Cu(111)

The fabrication of copper thin films with ultraflat surfaces and only occasional mono-atomic steps, which show semi-permanent resistance to oxidation over long periods, is reported and the mechanism explained using first-principles calculations.

Su Jae Kim
Yong In Kim
Se-Young Jeong
ResearchOpen Access16 Mar 2022
Nature

Volume: 603, P: 434-438
Haplotype-resolved genome assembly and resequencing analysis provide insights into genome evolution and allelic imbalance in Pinus densiflora

Chromosome-scale and haplotype-resolved assembly of Pinus densiflora sheds light on Pinus-specific genome enlargement. Comparison between haplotypes and resequencing of 30 wild accessions show allelic imbalance with roles in flowering regulation and stress resistance.

Min-Jeong Jang
Hye Jeong Cho
Seungill Kim
Research20 Oct 2024
Nature Genetics

Volume: 56, P: 2551-2561
Effects of metformin on colorectal cancer stem cells depend on alterations in glutamine metabolism

Jae Hyun Kim
Kyoung Jin Lee
Tae Il Kim
ResearchOpen Access11 Jan 2018
Scientific Reports

Volume: 8, P: 1-13
Sd-021, derivatives of decursin, inhibits tumorigenesis in NSCLC by inhibiting the EGFR/STAT3 signaling pathway

Hyun-Ha Hwang
Jeong-Hui Je
Seong-Gyu Ko
ResearchOpen Access02 Jul 2025
Scientific Reports

Volume: 15, P: 1-14
Olfactomedin 4 produces dysplasia but suppresses metastasis of colon cancer

Hyun Woo Ma
Jung Min Kim
Seung Won Kim
Research28 Dec 2022
Cancer Gene Therapy

Volume: 30, P: 694-703
Correlation of genotypes for thiopurine methyltransferase and inosine triphosphate pyrophosphatase with long-term clinical outcomes in Korean patients with inflammatory bowel diseases during treatment with thiopurine drugs

Yoon Suk Jung
Jae Hee Cheon
Won Ho Kim
Research04 Dec 2009
Journal of Human Genetics

Volume: 55, P: 121-123
Molecular variations in Th1-specific cell surface gene Tim-3

Soo-Cheon Chae
Ju-Hee Song
Hun-Taeg Chung
ResearchOpen Access01 Jun 2004
Experimental & Molecular Medicine

Volume: 36, P: 274-278
Neuronal SphK1 acetylates COX2 and contributes to pathogenesis in a model of Alzheimer’s Disease

Sphingosine kinase (SphK) converts sphingosine into lipids, and is implicated in inflammation. Here the authors show that SphK1 functions as an acetyltransferase, regulates microglial phagocytosis and is reduced in a model of Alzheimer’s Disease, such that its restoration ameliorates pathology

Ju Youn Lee
Seung Hoon Han
Hee Kyung Jin
ResearchOpen Access16 Apr 2018
Nature Communications

Volume: 9, P: 1-14
Identification of a subnuclear body involved in sequence-specific cytokine RNA processing

Processing of interleukin RNAs must be tightly controlled during the immune response. Here, the authors identify TDP-43 as a scaffold protein for the formation of a nuclear body that is important for interleukin RNA processing and stability.

Sungwook Lee
Taeyun A. Lee
Boyoun Park
Research05 Jan 2015
Nature Communications

Volume: 6, P: 1-14
TRIM31 promotes Atg5/Atg7-independent autophagy in intestinal cells

While non-canonical, Atg5/Atg7-independent autophagy has been reported to occur, molecular details of alternative autophagy pathways remain unknown. Here, the authors report that the protein TRIM31 mediates alternative autophagy in intestinal cells, which protects against pathogenic bacteria.

Eun A. Ra
Taeyun A. Lee
Boyoun Park
ResearchOpen Access24 May 2016
Nature Communications

Volume: 7, P: 1-15
Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations

Rinse Weersma, Carl Anderson and colleagues report the results of a trans-ancestry association study of inflammatory bowel disease. They implicate 38 new susceptibility loci, and show that the variance explained by each IBD risk locus is consistent across diverse ancestries, with a few notable exceptions.

Jimmy Z Liu
Suzanne van Sommeren
Rinse K Weersma
Research20 Jul 2015
Nature Genetics

Volume: 47, P: 979-986
Low prevalence of classical galactosemia in Korean population

Beom Hee Lee
Chong Kun Cheon
Han-Wook Yoo
Research09 Dec 2010
Journal of Human Genetics

Volume: 56, P: 94-96
Interleukin-33 regulates intestinal inflammation by modulating macrophages in inflammatory bowel disease

Dong Hyuk Seo
Xiumei Che
Jae Hee Cheon
ResearchOpen Access12 Apr 2017
Scientific Reports

Volume: 7, P: 1-13
Proteomic analysis-based discovery of a novel biomarker that differentiates intestinal Behçet’s disease from Crohn’s disease

Jihye Park
Daeun Jeong
Ji-Hwan Ryu
ResearchOpen Access26 May 2021
Scientific Reports

Volume: 11, P: 1-12
Microbial changes in stool, saliva, serum, and urine before and after anti-TNF-α therapy in patients with inflammatory bowel diseases

Yong Eun Park
Hye Su Moon
Jae Hee Cheon
ResearchOpen Access15 Apr 2022
Scientific Reports

Volume: 12, P: 1-14
Identification of genetic susceptibility loci for intestinal Behçet’s disease

Seung Won Kim
Yoon Suk Jung
Jae Hee Cheon
ResearchOpen Access03 Jan 2017
Scientific Reports

Volume: 7, P: 1-11
Incidence, prevalence, and global burden of ADHD from 1990 to 2019 across 204 countries: data, with critical re-analysis, from the Global Burden of Disease study

Samuele Cortese
Minjin Song
Marco Solmi
Research08 Sept 2023
Molecular Psychiatry

Volume: 28, P: 4823-4830
Unveiling the role of transgelin as a prognostic and therapeutic target in kidney fibrosis via a proteomic approach

Soie Kwon
Seongmin Cheon
Seung-Hee Yang
ResearchOpen Access07 Oct 2024
Experimental & Molecular Medicine

Volume: 56, P: 2296-2308
Incidence, prevalence, and global burden of autism spectrum disorder from 1990 to 2019 across 204 countries

Marco Solmi
Minjin Song
Samuele Cortese
Research29 Jun 2022
Molecular Psychiatry

Volume: 27, P: 4172-4180
CD9 induces cellular senescence and aggravates atherosclerotic plaque formation

Jung Hee Cho
Eok-Cheon Kim
Jae-Ryong Kim
Research28 Apr 2020
Cell Death & Differentiation

Volume: 27, P: 2681-2696
Autosomal dominant transmission of complicated hereditary spastic paraplegia due to a dominant negative mutation of KIF1A, SPG30 gene

Chong Kun Cheon
So-Hee Lim
Jae-Ran Lee
ResearchOpen Access02 Oct 2017
Scientific Reports

Volume: 7, P: 1-11
Continuous cropping of endangered therapeutic plants via electron beam soil-treatment and neutron tomography

Cheul Muu Sim
Bong Jae Seong
Bernd Honermeier
ResearchOpen Access01 Feb 2018
Scientific Reports

Volume: 8, P: 1-14
Proteome-wide characterization of signalling interactions in the hippocampal CA4/DG subfield of patients with Alzheimer’s disease

Jae Ho Kim
Julien Franck
Young Mok Park
ResearchOpen Access10 Jun 2015
Scientific Reports

Volume: 5, P: 1-15
Behçet syndrome

Behçet syndrome is a recurrent multiorgan inflammatory disorder and a systemic vasculitis that predominantly affects veins. This Primer reviews the epidemiology, pathophysiology, diagnosis and treatment of Behçet syndrome and describes its effect on patient quality of life and the future outlook for the field.

Yusuf Yazici
Gulen Hatemi
Hasan Yazici
Reviews16 Sept 2021
Nature Reviews Disease Primers

Volume: 7, P: 1-14
Blockade of translationally controlled tumor protein attenuated the aggressiveness of fibroblast-like synoviocytes and ameliorated collagen-induced arthritis

Mingyo Kim
Yongho Choe
Sang-Il Lee
ResearchOpen Access06 Jan 2021
Experimental & Molecular Medicine

Volume: 53, P: 67-80
Comparative and kinetic analysis of viral shedding and immunological responses in MERS patients representing a broad spectrum of disease severity

Chan-Ki Min
Shinhye Cheon
Yeon-Sook Kim
ResearchOpen Access05 May 2016
Scientific Reports

Volume: 6, P: 1-12
Melatonin controls microbiota in colitis by goblet cell differentiation and antimicrobial peptide production through Toll-like receptor 4 signalling

Seung Won Kim
Soochan Kim
Young Sook Park
ResearchOpen Access10 Feb 2020
Scientific Reports

Volume: 10, P: 1-10
Discovery of a novel fibroblast activation protein (FAP) inhibitor, BR103354, with anti-diabetic and anti-steatotic effects

Jae Min Cho
Eun Hee Yang
Hyae Gyeong Cheon
ResearchOpen Access04 Dec 2020
Scientific Reports

Volume: 10, P: 1-17
Identification of OCTN2 variants and their association with phenotypes of Crohn’s disease in a Korean population

Hyo Jin Park
Eun Suk Jung
Ji Ha Choi
ResearchOpen Access11 Mar 2016
Scientific Reports

Volume: 6, P: 1-10
Dysfunction of Microglial STAT3 Alleviates Depressive Behavior via Neuron–Microglia Interactions

Sun-Ho Kwon
Jeong-Kyu Han
Sang-Kyu Ye
ResearchOpen Access08 May 2017
Neuropsychopharmacology

Volume: 42, P: 2072-2086

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