Van den Brink and colleagues show that Nrf2, a regulator of the oxidative stress response, is required for several aspects of haematopoietic stem cell maintenance. Loss of Nrf2 results in the hyper-proliferation of haematopoietic stem and progenitor cells (HSPCs). Nrf2 is also required for HSPC migration and retention to their niche.
- Jennifer J. Tsai
- Jarrod A. Dudakov
- Marcel R. M. van den Brink
