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Advanced filters: Author: Jaee Ghawali Clear advanced filters

  • Diabetes is characterized by dysfunction and loss of beta-cells, and promoting beta-cell survival is of therapeutic interest. Here the authors show that Large-tumor suppressor 2 (LATS2), a core component of the Hippo signaling pathway, induces beta-cell failure through mTORC1 hyperactivation and autophagic flux suppression.

    • Ting Yuan
    • Karthika Annamalai
    • Amin Ardestani
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-18