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Showing 1–4 of 4 results
Advanced filters: Author: Jaime Vaquer-Alicea Clear advanced filters

  • The authors developed a computational approach to probe the stability of amyloid fibrils and discover networks of hotspot interactions. Understanding the mechanisms of amyloid folding will help identify novel methods to treat protein (mis)folding diseases.

    • Vishruth Mullapudi
    • Jaime Vaquer-Alicea
    • Lukasz A. Joachimiak
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-19

  • This study reveals near-atomic interfacial details of an Alzheimer’s Positron Emission Tomography (PET) molecule MK-6240 with its target disease marker, tau amyloid, showing MK-6240 mostly interacts with itself, like a pancake stack, which stabilizes an otherwise small interface with the amyloid.

    • Peter Kunach
    • Jaime Vaquer-Alicea
    • Sarah H. Shahmoradian
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-7

  • The Hsp70/Hsp40 system plays an important role in maintaining cellular proteostasis but so far it is not well understood how Hsp70 proteins are recruited to specific Hsp40 co-chaperones. Here, the authors combine biochemical and biophysical approaches to characterise the oligomeric mammalian Hsp40 DnaJB8. They identify an intra-oligomer DnaJB8 interaction between the N-terminal J-Domain and the C-terminal domain that occludes the J-Domain surface that binds Hsp70 and propose a model for DnaJB8-Hsp70 recruitment.

    • Bryan D. Ryder
    • Irina Matlahov
    • Lukasz A. Joachimiak
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-16