The authors use two-photon calcium imaging, EEG and electrophysiology to study ensemble neuronal activity in genetically altered mice that lack the Fmr1 protein: a model of Fragile X syndrome. Unanesthetized Fmr1−/− mice showed high synchrony of neocortical network activity and higher firing rates during sleep.
- J Tiago Gonçalves
- James E Anstey
- Carlos Portera-Cailliau