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Showing 1–5 of 5 results
Advanced filters: Author: James Berstler Clear advanced filters

  • Despite being a hallmark of cancer, the identification of targetable vulnerabilities of aneuploid cancer cells remains limited. Here, the authors develop RPE1-hTERT cell lines with varying degrees of aneuploidy to investigate the consequences of chromosomal imbalance, identifying CRAF as an aneuploid-selective therapeutically targetable vulnerability.

    • Johanna Zerbib
    • Marica Rosaria Ippolito
    • Stefano Santaguida
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-20

  • Inhibitors of CDK8 enhance IL-10 production during innate immune activation in human and mouse primary macrophages and dendritic cells via diminished phosphorylation of the c-Jun subunit of the AP-1 transcription regulatory complex.

    • Liv Johannessen
    • Thomas B Sundberg
    • Ramnik J Xavier
    Research
    Nature Chemical Biology
    Volume: 13, P: 1102-1108

  • The CPJUMP1 Resource comprises Cell Painting images and profiles of 75 million cells treated with hundreds of chemical and genetic perturbations. The dataset enables exploration of their relationships and lays the foundation for the development of advanced methods to match perturbations.

    • Srinivas Niranj Chandrasekaran
    • Beth A. Cimini
    • Anne E. Carpenter
    ResearchOpen Access
    Nature Methods
    Volume: 21, P: 1114-1121