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Showing 1–6 of 6 results
Advanced filters: Author: James D. Wuest Clear advanced filters
  • Modular construction using connectable molecular subunits is a powerful strategy for making new carbon-based materials. So far, large crystals have been produced only from subunits linked by weak interactions. Covalently bonded analogues have now been prepared by reversible self-addition polymerization of suitable monomers and structurally characterized by single-crystal X-ray diffraction.

    • Daniel Beaudoin
    • Thierry Maris
    • James D. Wuest
    Research
    Nature Chemistry
    Volume: 5, P: 830-834
  • A preclinical covalent compound, CMX410, contains a aryl fluorosulfate warhead that targets the acyltransferase domain of Mtb Pks13, an essential enzyme in cell-wall biosynthesis, making it a promising candidate for tuberculosis treatment regimens.

    • Inna V. Krieger
    • Paridhi Sukheja
    • Case W. McNamara
    Research
    Nature
    Volume: 645, P: 755-763
  • Stacking of a chromophoric molecule in the solid state has been altered rationally by the formation of co-crystals, allowing fine control of luminescence.

    • James D. Wuest
    News & Views
    Nature Chemistry
    Volume: 4, P: 74-75
  • While speciation rates vary across regions, the causes of this disparity and its impact on biodiversity patterns still puzzle scientists. Studying South American fish speciation, Cerezer et al. uncover key associations of body size evolution—especially rapid changes in uplands—with accelerated speciation.

    • Felipe O. Cerezer
    • Cristian S. Dambros
    • Catherine H. Graham
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-11
  • Federated learning can be used to train medical AI models on sensitive personal data while preserving important privacy properties; however, the sensitive nature of the data makes it difficult to evaluate approaches reproducibly on real data. The MedPerf project presented by Karargyris et al. provides the tools and infrastructure to distribute models to healthcare facilities, such that they can be trained and evaluated in realistic settings.

    • Alexandros Karargyris
    • Renato Umeton
    • Peter Mattson
    ResearchOpen Access
    Nature Machine Intelligence
    Volume: 5, P: 799-810
  • The strategy of modular construction makes it possible to create ordered materials with structures that are controlled at the molecular level. In this perspective article, the author shows how the approach has yielded a new generation of materials with extraordinary properties of porosity.

    • James D. Wuest
    ReviewsOpen Access
    Nature Communications
    Volume: 11, P: 1-8