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Showing 1–3 of 3 results
Advanced filters: Author: James H. Atkison Clear advanced filters

  • The E2 enzyme Cdc34 plays a critical role in cell cycle progression but the structural bases for its activities are unknown. Here, the authors present crystal structures of Cdc34 alone, in complex with E1, and in complex with Ub that provide insights into the mechanism of Cdc34 activity in the cell.

    • Katelyn M. Williams
    • Shuo Qie
    • Shaun K. Olsen
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-15

  • Ubiquitin and ubiquitin-like modifiers such as SUMO play important roles in several cellular pathways that can become deregulated in cancer. Here the authors describe the structural basis for inhibition of SUMO E1 ligase by the small molecule COH000.

    • Zongyang Lv
    • Lingmin Yuan
    • Shaun K. Olsen
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-12

  • HHARI is a RING-in-between-RING (RBR) ubiquitin (Ub) E3 ligase. Here the authors present the crystal structure of HHARI with the UbcH7 ~ Ub thioester intermediate mimetic, which reveals that HHARI binds this E2 ~ Ub in an open conformation and explains the specificity of this cognate RBR E3/E2 pair.

    • Lingmin Yuan
    • Zongyang Lv
    • Shaun K. Olsen
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-14