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Showing 1–6 of 6 results
Advanced filters: Author: James H. Felce Clear advanced filters
  • Peng et al. find that immunodominant cytotoxic T lymphocytes (CTLs) specific for NP105–113-B*07:02 are associated with reduced COVID-19 severity. Mechanistically, NP105–113-B*07:02-specific CTLs show potent antiviral functionality and may represent rational T cell vaccine targets.

    • Yanchun Peng
    • Suet Ling Felce
    • Tao Dong
    ResearchOpen Access
    Nature Immunology
    Volume: 23, P: 50-61
  • The structure of a RIFIN–LILRB1 complex reveals that a subset of RIFINs of Plasmodium falciparum mimics the binding mode of the natural ligand of human LILRB1 and suppress the function of natural killer cells in humans.

    • Thomas E. Harrison
    • Alexander M. Mørch
    • Matthew K. Higgins
    Research
    Nature
    Volume: 587, P: 309-312
  • Yu et al examined a panel of both experimental and clinically-relevant TNF agonists in order to advance our understanding of the mechanisms underlying their varying activities and anti-tumor responses. They demonstrated that agonists with greater activity induced higher density receptor clustering and specific super-structures as opposed to simply larger receptor clusters.

    • Xiaojie Yu
    • Sonya James
    • Mark S. Cragg
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-15
  • Various physiological processes including development and maintenance of epithelia, cell–cell fusion, neuronal function and immune responses rely on the establishment of direct cell–cell contacts. Despite their diversity, the different cell–cell interfaces can be viewed as specialized compartments that perform their distinct functions through common biophysical properties.

    • Brian Belardi
    • Sungmin Son
    • Daniel A. Fletcher
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 21, P: 750-764