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Showing 1–11 of 11 results
Advanced filters: Author: James Hewinson Clear advanced filters

  • It is unclear whether somatic mutation rates are elevated in Lynch Syndrome (LS), which is the most common cause of hereditary colorectal cancer. Here, the authors use whole-genome sequencing and organoid cultures to show that normal tissues in LS patients are genomically stable, while ancestor cells of neoplastic tissues undergo multiple cycles of clonal evolution.

    • Bernard C. H. Lee
    • Philip S. Robinson
    • Michael R. Stratton
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-10

  • Systematic screens for synthetic lethal gene pairs represent a powerful approach to define interactions that may be exploited in the clinic. Here, the authors use a dual-guide CRISPR screening approach to screen a curated selection of gene pairs across three cell lines and validate the Fam50a/Fam50b synthetic lethality was in isogenic cell models as well as in an in vivo setting.

    • Nicola A. Thompson
    • Marco Ranzani
    • David J. Adams
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-11

  • Spiradenoma and cylindroma are skin adnexal tumors that can behave aggressively and undergo malignant transformation. Here, the authors genetically assess a cohort of these adnexal tumours, highlighting recurrent ALPK1 mutations and revealing the genomic landscape of these rare tumours.

    • Mamunur Rashid
    • Michiel van der Horst
    • David J. Adams
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-10

  • Whole-genome sequencing of 1,013 clonal haematopoietic colonies from myeloproliferative neoplasms of 12 individuals reveals haematopoietic phylogenies and indicates that driver mutations are acquired sequentially, starting early in life.

    • Nicholas Williams
    • Joe Lee
    • Jyoti Nangalia
    Research
    Nature
    Volume: 602, P: 162-168

  • Understanding tumor metastasis is crucial to developing more effective cancer therapies. Here McCreery et al. analyzed the mutational profile of metastases from chemically induced skin tumors in mice and found that parallel evolution of synchronously disseminated tumor cells underlies most metastasis.

    • Melissa Q McCreery
    • Kyle D Halliwill
    • Allan Balmain
    Research
    Nature Medicine
    Volume: 21, P: 1514-1520

  • Carbon capture and storage can help reduce CO2 emissions but the confidence in geologic CO2 storage security is uncertain. Here the authors present a numerical programme to estimate leakage from wells and find that under appropriate regulation 98% of injected CO2 will be retained over 10,000 years.

    • Juan Alcalde
    • Stephanie Flude
    • R. Stuart Haszeldine
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-13