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Advanced filters: Author: James Mullmann Clear advanced filters

Acylspermidines are conserved mitochondrial sirtuin-dependent metabolites

Untargeted comparative metabolomics revealed N-acylspermidines as conserved metabolites downstream of mitochondrial sirtuins that provide direct evidence for their in vivo deacylation functions and may contribute to sirtuin-dependent phenotypes.

Bingsen Zhang
James Mullmann
Frank C. Schroeder
Research02 Jan 2024
Nature Chemical Biology

Volume: 20, P: 812-822
Pharmacological and genetic perturbation establish SIRT5 as a promising target in breast cancer

Yashira L. Negrón Abril
Irma R. Fernandez
Robert S. Weiss
Research21 Jan 2021
Oncogene

Volume: 40, P: 1644-1658

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Acylspermidines are conserved mitochondrial sirtuin-dependent metabolites

Pharmacological and genetic perturbation establish SIRT5 as a promising target in breast cancer

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