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Showing 1–3 of 3 results
Advanced filters: Author: James P. Robblee Clear advanced filters

  • Here, Robert-Paganin et al. show that myosin A from Plasmodium falciparum is critical for red blood cell invasion and that non-canonical interactions and regulated phosphorylation are important for force generation during parasite invasion.

    • Julien Robert-Paganin
    • James P. Robblee
    • Anne Houdusse
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-12

  • Plasmodium falciparum moves by an atypical process called gliding motility which comprises of atypical myosin A (PfMyoA) and filaments of the dynamic and divergent PfActin-1 (PfAct1). Here authors present the cryo-EM structure of PfMyoA bound to filamentous PfAct1 stabilized with jasplakinolide and provide insights into the interactions that are required for the parasite to produce the force and motion required for infectivity.

    • Julien Robert-Paganin
    • Xiao-Ping Xu
    • Dorit Hanein
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-11