Nature Search

Campomelic dysplasia and autosomal sex reversal caused by mutations in an SRY-related gene

Jamie W. Foster
Marina A. Dominguez-Steglich
Alan J. Schafer
Research08 Dec 1994
Nature

Volume: 372, P: 525-530
Potassium dependent structural changes in the selectivity filter of HERG potassium channels

HERG channel inactivation is critical for normal heart rhythm. Authors determine structures of open and non-conducting states of HERG and identify a key role for S620 on the pore helix in coordinating transitions between open and inactivated states.

Carus H. Y. Lau
Emelie Flood
Jamie I. Vandenberg
ResearchOpen Access29 Aug 2024
Nature Communications

Volume: 15, P: 1-13
GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
ResearchOpen Access17 May 2023
Nature

Volume: 617, P: 764-768
Profiling senescent cells in human brains reveals neurons with CDKN2D/p19 and tau neuropathology

Using a new computational approach to identify senescent cells from single-cell transcriptomic data, the authors find that most senescent cells in the human brain are excitatory neurons with elevated CDKN2D/p19 expression, which often display Alzheimer’s disease-associated tau pathology.

Shiva Kazempour Dehkordi
Jamie Walker
Miranda E. Orr
Research10 Dec 2021
Nature Aging

Volume: 1, P: 1107-1116
Whole-genome sequencing reveals host factors underlying critical COVID-19

Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

Athanasios Kousathanas
Erola Pairo-Castineira
J. Kenneth Baillie
ResearchOpen Access07 Mar 2022
Nature

Volume: 607, P: 97-103
Designed endocytosis-inducing proteins degrade targets and amplify signals

Computationally designed genetically encoded proteins can be used to target surface proteins, thereby triggering endocytosis and subsequent intracellular degradation, activating signalling or increasing cellular uptake in specific tissues.

Buwei Huang
Mohamad Abedi
David Baker
ResearchOpen Access25 Sept 2024
Nature

Volume: 638, P: 796-804
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Erratum: A selective inhibitor of the immunoproteasome subunit LMP7 blocks cytokine production and attenuates progression of experimental arthritis

Tony Muchamuel
Michael Basler
Marcus Groettrup
Amendments and Corrections01 Nov 2009
Nature Medicine

Volume: 15, P: 1333
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Alignment of fractures on Bennu’s boulders indicative of rapid asteroid surface evolution

Fractures on the asteroid Bennu imaged by the OSIRIS-REx spacecraft are consistent with cracking induced by diurnal temperature variations over geologically rapid timescales.

Marco Delbo
Kevin J. Walsh
Dante S. Lauretta
Research23 May 2022
Nature Geoscience

Volume: 15, P: 453-457
A selective inhibitor of the immunoproteasome subunit LMP7 blocks cytokine production and attenuates progression of experimental arthritis

Christopher Kirk and his colleagues have developed the first specific inhibitor of the immunoproteasome. They find that the immunoproteasome has a major role in regulating cytokine production, as well as antigen presentation, and their inhibitor has good efficacy in animal models of arthritis.

Tony Muchamuel
Michael Basler
Marcus Groettrup
Research14 Jun 2009
Nature Medicine

Volume: 15, P: 781-787
Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease

Openshaw and colleagues find myeloid inflammation and complement activation signatures in patients with long COVID who were previously hospitalized.

Felicity Liew
Claudia Efstathiou
J. Eunice Zhang
ResearchOpen Access08 Apr 2024
Nature Immunology

Volume: 25, P: 607-621
Psychological characteristics associated with COVID-19 vaccine hesitancy and resistance in Ireland and the United Kingdom

Hesitancy and resistance towards vaccination is a challenge for public health. Here the authors determine psychological characteristics associated with COVID-19 vaccine hesitancy or resistance attitudes in the UK and Ireland.

Jamie Murphy
Frédérique Vallières
Philip Hyland
ResearchOpen Access04 Jan 2021
Nature Communications

Volume: 12, P: 1-15
iCLOTS: open-source, artificial intelligence-enabled software for analyses of blood cells in microfluidic and microscopy-based assays

Microscopy has undoubtedly advanced biomedical research, but novel hypotheses are often lost to a lack of analytical tools. Here authors propose iCLOTS, a freely-available software that allows researchers to apply image processing and artificial intelligence algorithms to their own data.

Meredith E. Fay
Oluwamayokun Oshinowo
Wilbur A. Lam
ResearchOpen Access18 Aug 2023
Nature Communications

Volume: 14, P: 1-16
Quantum sensing for gravity cartography

A study reports a quantum gravity gradient sensor with a design that eliminates the need for long measurement times, and demonstrates the detection of an underground tunnel in an urban environment.

Ben Stray
Andrew Lamb
Michael Holynski
ResearchOpen Access23 Feb 2022
Nature

Volume: 602, P: 590-594
A scalable double-barcode sequencing platform for characterization of dynamic protein-protein interactions

Protein-protein interactions (PPIs) play a major role in defining biological functions. Here, the authors present PPiSeq, a method to quantitatively score dynamic PPIs in yeast combining fragment complementation assays, genomic double-barcoding, and an analytical framework to precisely call fitness from barcode lineage trajectories.

Ulrich Schlecht
Zhimin Liu
Sasha F. Levy
ResearchOpen Access25 May 2017
Nature Communications

Volume: 8, P: 1-9
Treating cat allergy with monoclonal IgG antibodies that bind allergen and prevent IgE engagement

Allergen-specific immunotherapy is used to treat patients affected by acute immunoglobulin E (IgE) responses, but the function mechanism is unclear. Here the authors show that the administration of two cat allergen-specific IgGs reduces allergic responses in mouse models and helps ameliorate clinical symptoms in a phase 1b clinical trial.

J. M. Orengo
A. R. Radin
G. D. Yancopoulos
ResearchOpen Access12 Apr 2018
Nature Communications

Volume: 9, P: 1-15
A crucial requirement for Hedgehog signaling in small cell lung cancer

The authors find that cell-intrinsic activation of Hedgehog signaling without genetic alterations is a contributing feature to the progression and chemotherapy resistance of small-cell lung carcinoma, and that Hedgehog inhibition can prevent lung cancer growth and recurrence.

Kwon-Sik Park
Luciano G Martelotto
Julien Sage
Research09 Oct 2011
Nature Medicine

Volume: 17, P: 1504-1508
Author Correction: GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
Amendments and CorrectionsOpen Access11 Jul 2023
Nature

Volume: 619, P: E61
A combined risk score enhances prediction of type 1 diabetes among susceptible children

In a study of children with high genetic risk aged 2 years or older, a risk score integrating pancreatic islet autoantibodies, genetic factors and family history is highly predictive of type 1 diabetes in the subsequent 8 years.

Lauric A. Ferrat
Kendra Vehik
Roy Tamura
Research07 Aug 2020
Nature Medicine

Volume: 26, P: 1247-1255
Senescent cells: an emerging target for diseases of ageing

Cellular senescence is causally linked to ageing and has been implicated in a variety of age-related diseases. Here, van Deursen and colleagues review the characteristics of senescent cells and highlight evidence for a role of these cells in diseases, including cancer, atherosclerosis and osteoarthritis. Emerging strategies for therapeutically targeting senescent cells and the associated challenges are discussed.

Bennett G. Childs
Martina Gluscevic
Jan M. van Deursen
Reviews21 Jul 2017
Nature Reviews Drug Discovery

Volume: 16, P: 718-735
A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease

The Coronary Artery Disease Genetics Consortium report a meta-analysis of genome-wide association studies for coronary artery disease (CAD) in discovery and replication cohorts including both European and South Asian studies. They identify five loci newly associated with CAD.

John F Peden
Jemma C Hopewell
Sonia S Anand
Research06 Mar 2011
Nature Genetics

Volume: 43, P: 339-344
Long-term, non-invasive FTIR detection of low-dose ionizing radiation exposure

Jamie L. Inman
Yulun Wu
Antoine M. Snijders
ResearchOpen Access13 Mar 2024
Scientific Reports

Volume: 14, P: 1-12
A Comparison of Rule-based Analysis with Regression Methods in Understanding the Risk Factors for Study Withdrawal in a Pediatric Study

Mona Haghighi
Suzanne Bennett Johnson
Thomas Briese
ResearchOpen Access26 Aug 2016
Scientific Reports

Volume: 6, P: 1-12
Low-frequency ERK and Akt activity dynamics are predictive of stochastic cell division events

Jamie J. R. Bennett
Alan D. Stern
Gaurav Pandey
ResearchOpen Access04 Jun 2024
npj Systems Biology and Applications

Volume: 10, P: 1-10
Metaplastic breast cancers frequently express immune checkpoint markers FOXP3 and PD-L1

Emarene Kalaw
Malcolm Lim
Amy E. McCart Reed
ResearchOpen Access17 Sept 2020
British Journal of Cancer

Volume: 123, P: 1665-1672
Small fibre pathology, small fibre symptoms and pain in fibromyalgia syndrome

Anne Marshall
Leandros Rapteas
Uazman Alam
ResearchOpen Access16 Feb 2024
Scientific Reports

Volume: 14, P: 1-12
Ontology of the apelinergic system in mouse pancreas during pregnancy and relationship with β-cell mass

Brenda Strutt
Sandra Szlapinski
David J. Hill
ResearchOpen Access29 Jul 2021
Scientific Reports

Volume: 11, P: 1-15
Dynamic changes in immune gene co-expression networks predict development of type 1 diabetes

Ingrid Brænne
Suna Onengut-Gumuscu
Eric Triplett
ResearchOpen Access22 Nov 2021
Scientific Reports

Volume: 11, P: 1-13
Risk of celiac disease autoimmunity is modified by interactions between CD247 and environmental exposures

Anna Eurén
Kristian Lynch
Eric Triplett
ResearchOpen Access26 Oct 2024
Scientific Reports

Volume: 14, P: 1-14
Complement gene variants in relation to autoantibodies to beta cell specific antigens and type 1 diabetes in the TEDDY Study

Carina Törn
Xiang Liu
Mari Åkerlund
ResearchOpen Access16 Jun 2016
Scientific Reports

Volume: 6, P: 1-10
Telomere length is not a main factor for the development of islet autoimmunity and type 1 diabetes in the TEDDY study

Carina Törn
Xiang Liu
Eric W. Triplett
ResearchOpen Access16 Mar 2022
Scientific Reports

Volume: 12, P: 1-11
Four consecutive yearly point-prevalence studies in Wales indicate lack of improvement in sepsis care on the wards

Maja Kopczynska
Harry Unwin
Judith E. Hall
ResearchOpen Access10 Aug 2021
Scientific Reports

Volume: 11, P: 1-12
Breast cancer risk feedback to women in the UK NHS breast screening population

D Gareth R Evans
Louise S Donnelly
Anthony Howell
ResearchOpen Access29 Mar 2016
British Journal of Cancer

Volume: 114, P: 1045-1052
Children’s erythrocyte fatty acids are associated with the risk of islet autoimmunity

Sari Niinistö
Iris Erlund
Eric Triplett
ResearchOpen Access11 Feb 2021
Scientific Reports

Volume: 11, P: 1-12
Metabolite-related dietary patterns and the development of islet autoimmunity

Randi K. Johnson
Lauren Vanderlinden
Eric Triplett
ResearchOpen Access15 Oct 2019
Scientific Reports

Volume: 9, P: 1-11
A systematic review of optical coherence tomography findings in adults with mild traumatic brain injury

Hannah S. Lyons
Matilde Sassani
Richard J. Blanch
ReviewsOpen Access18 Jan 2024
Eye

Volume: 38, P: 1077-1083

Search

Campomelic dysplasia and autosomal sex reversal caused by mutations in an SRY-related gene

Potassium dependent structural changes in the selectivity filter of HERG potassium channels

GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Profiling senescent cells in human brains reveals neurons with CDKN2D/p19 and tau neuropathology

Whole-genome sequencing reveals host factors underlying critical COVID-19

Designed endocytosis-inducing proteins degrade targets and amplify signals

Mapping the human genetic architecture of COVID-19

Erratum: A selective inhibitor of the immunoproteasome subunit LMP7 blocks cytokine production and attenuates progression of experimental arthritis

A second update on mapping the human genetic architecture of COVID-19

Alignment of fractures on Bennu’s boulders indicative of rapid asteroid surface evolution

A selective inhibitor of the immunoproteasome subunit LMP7 blocks cytokine production and attenuates progression of experimental arthritis

Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease

Psychological characteristics associated with COVID-19 vaccine hesitancy and resistance in Ireland and the United Kingdom

iCLOTS: open-source, artificial intelligence-enabled software for analyses of blood cells in microfluidic and microscopy-based assays

Quantum sensing for gravity cartography

A scalable double-barcode sequencing platform for characterization of dynamic protein-protein interactions

Treating cat allergy with monoclonal IgG antibodies that bind allergen and prevent IgE engagement

A crucial requirement for Hedgehog signaling in small cell lung cancer

Author Correction: GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

A combined risk score enhances prediction of type 1 diabetes among susceptible children

Senescent cells: an emerging target for diseases of ageing

A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease

Long-term, non-invasive FTIR detection of low-dose ionizing radiation exposure

A Comparison of Rule-based Analysis with Regression Methods in Understanding the Risk Factors for Study Withdrawal in a Pediatric Study

Low-frequency ERK and Akt activity dynamics are predictive of stochastic cell division events

Metaplastic breast cancers frequently express immune checkpoint markers FOXP3 and PD-L1

Small fibre pathology, small fibre symptoms and pain in fibromyalgia syndrome

Ontology of the apelinergic system in mouse pancreas during pregnancy and relationship with β-cell mass

Dynamic changes in immune gene co-expression networks predict development of type 1 diabetes

Risk of celiac disease autoimmunity is modified by interactions between CD247 and environmental exposures

Complement gene variants in relation to autoantibodies to beta cell specific antigens and type 1 diabetes in the TEDDY Study

Telomere length is not a main factor for the development of islet autoimmunity and type 1 diabetes in the TEDDY study

Four consecutive yearly point-prevalence studies in Wales indicate lack of improvement in sepsis care on the wards

Breast cancer risk feedback to women in the UK NHS breast screening population

Children’s erythrocyte fatty acids are associated with the risk of islet autoimmunity

Metabolite-related dietary patterns and the development of islet autoimmunity

A systematic review of optical coherence tomography findings in adults with mild traumatic brain injury

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