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Clonal dynamics and somatic evolution of haematopoiesis in mouse

Isolating and studying haematopoietic stem cells in young and aged mice demonstrates evolutionary processes related to blood production and provides a framework for interpreting future work using laboratory mice to study stem cell ageing.

Chiraag D. Kapadia
Nicholas Williams
Jyoti Nangalia
ResearchOpen Access05 Mar 2025
Nature

Volume: 641, P: 681-689
Astroblastomas exhibit radial glia stem cell lineages and differential expression of imprinted and X-inactivation escape genes

Astroblastoma (AB) is an uncommon brain tumour and its origin remains unknown. Here, the authors perform integrative molecular analysis of 35 AB-like tumours and provide evidence that these arise in the context of epigenetic and genetic changes in neural progenitors occurring during brain development.

Norman L. Lehman
Nathalie Spassky
Akshitkumar M. Mistry
ResearchOpen Access19 Apr 2022
Nature Communications

Volume: 13, P: 1-20
Hyperactivity of indirect pathway-projecting spiny projection neurons promotes compulsive behavior

Striatal hyperactivity has been linked to compulsive behavior, but cell-type and pathway specific mechanisms are unclear. Here, the authors show excessive grooming in Sapap3-KO mice is associated with indirect pathway hyperactivity and suppression of hyperactivity normalizes grooming.

Sean C. Piantadosi
Elizabeth E. Manning
Susanne E. Ahmari
ResearchOpen Access24 May 2024
Nature Communications

Volume: 15, P: 1-17
Author Correction: Astroblastomas exhibit radial glia stem cell lineages and differential expression of imprinted and X-inactivation escape genes

Norman L. Lehman
Nathalie Spassky
Akshitkumar M. Mistry
Amendments and CorrectionsOpen Access31 Jan 2023
Nature Communications

Volume: 14, P: 1
Protection against malaria at 1 year and immune correlates following PfSPZ vaccination

Fifty-five percent of individuals vaccinated with an attenuated Plasmodium falciparum sporozoite vaccine remained without parasitemia after controlled human malaria infection one year later; immune correlate analysis in humans and non-human primates suggest a role for liver-resident T cells.

Andrew S Ishizuka
Kirsten E Lyke
Robert A Seder
Research09 May 2016
Nature Medicine

Volume: 22, P: 614-623
Phase 1 dose-escalation trial evaluating a group 2 influenza hemagglutinin stabilized stem nanoparticle vaccine

Joseph P. Casazza
Amelia R. Hofstetter
Rajoshi Chaudhuri
ResearchOpen Access17 Sept 2024
npj Vaccines

Volume: 9, P: 1-10

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Clonal dynamics and somatic evolution of haematopoiesis in mouse

Astroblastomas exhibit radial glia stem cell lineages and differential expression of imprinted and X-inactivation escape genes

Hyperactivity of indirect pathway-projecting spiny projection neurons promotes compulsive behavior

Author Correction: Astroblastomas exhibit radial glia stem cell lineages and differential expression of imprinted and X-inactivation escape genes

Protection against malaria at 1 year and immune correlates following PfSPZ vaccination

Phase 1 dose-escalation trial evaluating a group 2 influenza hemagglutinin stabilized stem nanoparticle vaccine

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