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Showing 101–114 of 114 results
Advanced filters: Author: Jamie Rossjohn Clear advanced filters

  • Type 1 diabetes has a multifactorial etiology. Lehuen and colleagues demonstrate that MAIT cells serve both positive roles and negative roles in type 1 diabetes by maintaining gut integrity and limiting pancreatic inflammation but also directly destroying β-cells.

    • Ophélie Rouxel
    • Jennifer Da silva
    • Agnès Lehuen
    Research
    Nature Immunology
    Volume: 18, P: 1321-1331

  • This Review focuses on the lesser studied antigen-presenting molecules group 1 CD1 proteins and MHC class I-related protein (MR1). The authors explain how their mode of presentation of lipids and small molecules to T cells differs from that of peptide–MHC presentation, and how new technologies are revealing unique T cell subsets that are specific for CD1 and MR1 proteins.

    • Ildiko Van Rhijn
    • Dale I. Godfrey
    • D. Branch Moody
    Reviews
    Nature Reviews Immunology
    Volume: 15, P: 643-654

  • Intriguing parallels can be drawn between the immune mechanisms leading to rheumatoid arthritis and coeliac disease, which point to a crucial role for T cell–B cell cooperation in both diseases. This article highlights recent developments in understanding the contributions of specific HLA molecules and antibodies against post-translationally modified protein antigens to these diseases.

    • Frits Koning
    • Ranjeny Thomas
    • Rene E. Toes
    Reviews
    Nature Reviews Rheumatology
    Volume: 11, P: 450-461

  • NK cells recognize class I and stress-associated ligands. Altfeld and colleagues identify the NK cell receptor NKp44 as directly interacting with the class II HLA-DP in a partially peptide-dependent manner and with functional consequences for NK cell activity.

    • Annika Niehrs
    • Wilfredo F. Garcia-Beltran
    • Marcus Altfeld
    Research
    Nature Immunology
    Volume: 20, P: 1129-1137

  • Graham Heap, Tariq Ahmad and colleagues show that common variants in the HLA-DQA1–HLA-DRB1 region confer susceptibility to thiopurine-induced pancreatitis in individuals undergoing treatment for inflammatory bowel diseases. These findings could help identify patients at risk of developing this serious adverse reaction to thiopurine therapy.

    • Graham A Heap
    • Michael N Weedon
    • Tariq Ahmad
    Research
    Nature Genetics
    Volume: 46, P: 1131-1134

  • This Review provides an overview of our current understanding of the unconventional T cell compartment and discusses the development and function of unconventional T cells from an evolutionary perspective.

    • Toufic Mayassi
    • Luis B. Barreiro
    • Bana Jabri
    Reviews
    Nature
    Volume: 595, P: 501-510

  • This Review explores the mechanistic links underlying the associations between HLA and kidney diseases. The authors discuss how these links might provide insights into disease pathogenesis and describe the clinical implications of these insights.

    • Kate J. Robson
    • Joshua D. Ooi
    • A. Richard Kitching
    Reviews
    Nature Reviews Nephrology
    Volume: 14, P: 636-655

  • This Review focuses on the cytomegaloviruses and the sophisticated strategies they have evolved to evade immune recognition. The authors suggest a better appreciation of these pathways could have clinical implications beyond antiviral immunity, for instance in understanding immune evasion in cancer.

    • Richard Berry
    • Gabrielle M. Watson
    • Jamie Rossjohn
    Reviews
    Nature Reviews Immunology
    Volume: 20, P: 113-127

  • While most studies of T lymphocytes have focused on peptide-MHC-reactive T cells, many other types of T cells do not fit this paradigm. Here Godfrey et al. review the immunology of such unconventional T cells.

    • Dale I Godfrey
    • Adam P Uldrich
    • D Branch Moody
    Reviews
    Nature Immunology
    Volume: 16, P: 1114-1123

  • Sakthivel et al. report two natural genetic variants of galectin-11 in sheep and demonstrate that their ability to dimerise correlates with the differences in their anti-parasitic activity that triggers larval arrest. This study provides a basis for genetic studies toward selective breeding of animals to improve their resistance to parasites.

    • Dhanasekaran Sakthivel
    • Sarah Preston
    • Travis Beddoe
    ResearchOpen Access
    Communications Biology
    Volume: 3, P: 1-8