Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–5 of 5 results
Advanced filters: Author: Jan Broder Engler Clear advanced filters

  • Here the authors show that endogenous or therapeutically delivered GDF-15 activates brainstem neurons that trigger splenic β-adrenergic signaling. This, in turn, suppresses autoreactive T cells and reduces neuroinflammation, identifying a possible target for multiple sclerosis treatment.

    • Jana K. Sonner
    • Audrey Kahn
    • Manuel A. Friese
    ResearchOpen Access
    Nature Immunology
    P: 1-13

  • The authors report that the presynaptic protein bassoon forms toxic aggregates in neuronal somata in multiple sclerosis. Stimulation of proteasomal activity reduces bassoon aggregates, neuroaxonal loss and disability during CNS inflammation.

    • Benjamin Schattling
    • Jan Broder Engler
    • Manuel A. Friese
    Research
    Nature Neuroscience
    Volume: 22, P: 887-896

  • Slowing neurodegeneration is the most pressing clinical need for multiple sclerosis (MS). In this Review, Woo, Engler and Friese provide a neuron-centric view on inflammation-induced neurodegeneration in MS and discuss key pathways and molecules that can be therapeutically targeted.

    • Marcel S. Woo
    • Jan Broder Engler
    • Manuel A. Friese
    Reviews
    Nature Reviews Neuroscience
    Volume: 25, P: 493-513

  • Mucosal-associated invariant T (MAIT) cells mediate protection from pathogens, but their role in autoimmunity is unclear. Here the authors show that, in a mouse experimental autoimmune encephalomyelitis model, MAIT cells accumulate in the inflamed central nervous system and serve protective functions when activated via their T cell receptor.

    • Mark Walkenhorst
    • Jana K. Sonner
    • Anne Willing
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-16

  • Single-cell RNA sequencing was used to construct a map of gene expression in lesions from brains of patients with multiple sclerosis, revealing distinct lineage- and region-specific transcriptomic changes associated with selective cortical neuron damage and glial activation.

    • Lucas Schirmer
    • Dmitry Velmeshev
    • David H. Rowitch
    Research
    Nature
    Volume: 573, P: 75-82