Nature Search

X-ray structure of phospholipase A₂ complexed with a substrate-derived inhibitor

Marjolein M. G. M. Thunnissen
Eiso AB
Hubertus M. Verheij
Research18 Oct 1990
Nature

Volume: 347, P: 689-691
Active site and catalytic mechanism of phospholipase A₂

Bauke W. Dijkstra
Jan Drenth
Kor H. Kalk
Research12 Feb 1981
Nature

Volume: 289, P: 604-606
Local destabilisation of a DNA double helix by a T–T wobble pair

A. G. Cornelis
Jeroen H.J. Haasnoot
Altona Cornelis
Research01 Sept 1979
Nature

Volume: 281, P: 235-236
Metabolic modeling reveals a multi-level deregulation of host-microbiome metabolic networks in IBD

Here, using multi-omics, the authors reconstruct metabolic models and uncover how disrupted metabolic interactions between gut microbes and the host contribute to IBD, together suggesting that dietary modulation of the microbiome may help restore metabolic balance.

Jan Taubenheim
A. Samer Kadibalban
Christoph Kaleta
ResearchOpen Access02 Jun 2025
Nature Communications

Volume: 16, P: 1-18
Extreme adaptive modification in sex ratio of the Seychelles warbler's eggs

Jan Komdeur
Serge Daan
Christa Mateman
Research06 Feb 1997
Nature

Volume: 385, P: 522-525
Network state changes in sensory thalamus represent learned outcomes

The computational role of individual sensory thalamic nuclei in flexible encoding during adaptive behaviors is not fully understood. Here authors, using longitudinal deep brain two-photon calcium imaging, show that changes in mouse auditory thalamus single cell and neuronal population dynamics are predictive of task outcome in cross-modal associative learning.

Masashi Hasegawa
Ziyan Huang
Jan Gründemann
ResearchOpen Access07 Sept 2024
Nature Communications

Volume: 15, P: 1-14
A homozygous mutation in the endothelin-3 gene associated with a combined Waardenburg type 2 and Hirschsprung phenotype (Shah-Waardenburg syndrome)

Robert M.W. Hofstra
Jan Osinga
Charles H.C.M. Buys
Research01 Apr 1996
Nature Genetics

Volume: 12, P: 445-447
Respiratory physiology after resupination following prone ventilation to predict 28-day mortality in mechanically ventilated patients: a machine learning analysis

Lada Lijović
Tariq A. Dam
Patrick J. Thoral
ResearchOpen Access10 Feb 2026
Scientific Reports

Volume: 16, P: 1-12
HIV infection is active and progressive in lymphoid tissue during the clinically latent stage of disease

Giuseppe Pantaleo
Cecilia Graziosi
Anthony S. Fauci
Research25 Mar 1993
Nature

Volume: 362, P: 355-358
Electrophysiological resting-state signatures link polygenic scores to general intelligence

Rebecca Engler
Christina Stammen
Erhan Genç
ResearchOpen Access21 Nov 2025
Scientific Reports

Volume: 15, P: 1-20
A high-quality human reference panel reveals the complexity and distribution of genomic structural variants

Structural variants (SVs) are prevalent in genomes of the general population. Here, Guryev and The Genome of the Netherlands Consortium describe the reference panel of haplotype-resolved SVs from 769 individuals from 250 Dutch families and show its utility for studying heritable traits.

Jayne Y. Hehir-Kwa
Tobias Marschall
Victor Guryev
ResearchOpen Access06 Oct 2016
Nature Communications

Volume: 7, P: 1-10
C. elegans chromosomes connect to centrosomes by anchoring into the spindle network

A connection between centrosomes and chromosomes is a key feature of mitotic spindles. Here the authors generate 3D reconstructions of whole mitotic spindles in earlyC. elegansembryos and show that chromosomes are anchored by the entire spindle network and that connections through kinetochore microtubules are few and likely very transient.

Stefanie Redemann
Johannes Baumgart
Thomas Müller-Reichert
ResearchOpen Access11 May 2017
Nature Communications

Volume: 8, P: 1-13
Retraction Note: Antibodies against endogenous retroviruses promote lung cancer immunotherapy

Kevin W. Ng
Jesse Boumelha
George Kassiotis
Amendments and CorrectionsOpen Access14 Jan 2026
Nature

Volume: 649, P: 1330
Improved imputation quality of low-frequency and rare variants in European samples using the ‘Genome of The Netherlands’

Patrick Deelen
Androniki Menelaou
Morris A Swertz
ResearchOpen Access04 Jun 2014
European Journal of Human Genetics

Volume: 22, P: 1321-1326
Genome of the Netherlands population-specific imputations identify an ABCA6 variant associated with cholesterol levels

Frequencies of rare variants fluctuate over populations, hampering gene discovery. Here the authors use a population-specific reference panel, the Genome of the Netherlands, to discover four novel loci involved in lipid metabolism, including an exonic variant in ABCA6.

Elisabeth M. van Leeuwen
Lennart C. Karssen
Cornelia M. van Duijn
ResearchOpen Access09 Mar 2015
Nature Communications

Volume: 6, P: 1-6
Prediction of recurrence risk in endometrial cancer with multimodal deep learning

A multimodal deep learning prognostic model based on histopathology outperforms current gold standards for identifying patients with endometrial cancer with different outcomes, in multiple external validation cohorts.

Sarah Volinsky-Fremond
Nanda Horeweg
Tjalling Bosse
ResearchOpen Access24 May 2024
Nature Medicine

Volume: 30, P: 1962-1973
Inflammation status modulates the effect of host genetic variation on intestinal gene expression in inflammatory bowel disease

Inflammatory bowel diseases are heterogeneous, and little is known about how underlying genetic variation can affect their development. Here, the authors report that intestinal inflammation modulates the effect of host genetics on the gut mucosal expression of 190 genes in the context of inflammatory bowel diseases.

Shixian Hu
Werna T. Uniken Venema
Rinse K. Weersma
ResearchOpen Access18 Feb 2021
Nature Communications

Volume: 12, P: 1-10
Spatiotemporal material functionalization via competitive supramolecular complexation of avidin and biotin analogs

Controlled patterning of functionality within hydrogels typically involves complex chemistry. Here, the authors report on a simple competitive binding strategy using avidin and biotin analogs in an injectable biomaterial for spatiotemporally controlled presentation of biochemical stimuli to cells.

Tom Kamperman
Michelle Koerselman
Jeroen Leijten
ResearchOpen Access25 Sept 2019
Nature Communications

Volume: 10, P: 1-11
Whole-genome sequence variation, population structure and demographic history of the Dutch population

Paul de Bakker, Cisca Wijmenga and colleagues report on The Genome of the Netherlands Project, including whole-genome sequencing of 769 individuals of Dutch ancestry from 250 parent-offspring families and construction of a phased haplotype map. Their intermediate-coverage population sequencing data set provides a complementary resource to other publicly available data sets, including the 1000 Genomes Project.

Laurent C Francioli
Androniki Menelaou
Cisca Wijmenga
Research29 Jun 2014
Nature Genetics

Volume: 46, P: 818-825
Accelerated microbial turnover but constant growth efficiency with warming in soil

Whether rising temperatures will reduce global soil carbon stocks and enhance climate warming remains uncertain, in part because of a poor understanding of the mechanisms of soil microbial response to warming. Research now shows that microbial growth efficiency is insensitive to temperature change and that the response of microbial respiration to warming is driven by accelerated microbial turnover and enzyme kinetics.

Shannon B. Hagerty
Kees Jan van Groenigen
Paul Dijkstra
Research07 Sept 2014
Nature Climate Change

Volume: 4, P: 903-906
Breast tumor segmentation in ultrasound using distance-adapted fuzzy connectedness, convolutional neural network, and active contour

Marta Biesok
Jan Juszczyk
Pawel Badura
ResearchOpen Access28 Oct 2024
Scientific Reports

Volume: 14, P: 1-12
Large scale quantification of natural killer cell-induced apoptosis in patient-derived organoids reveals intratumoral response heterogeneity

Marisa Mercadante
Armin Scheben
Laura A. Martin
ResearchOpen Access26 Dec 2025
npj Precision Oncology

Volume: 10, P: 1-11
Author Correction: Prediction of recurrence risk in endometrial cancer with multimodal deep learning

Sarah Volinsky-Fremond
Nanda Horeweg
Tjalling Bosse
Amendments and CorrectionsOpen Access01 Jul 2024
Nature Medicine

Volume: 30, P: 2092
Increased soil emissions of potent greenhouse gases under increased atmospheric CO₂

Kees Jan van Groenigen
Craig W. Osenberg
Bruce A. Hungate
Research13 Jul 2011
Nature

Volume: 475, P: 214-216
Loss-of-function mutations in IGSF1 cause an X-linked syndrome of central hypothyroidism and testicular enlargement

Daniel Bernard, Jan Wit, Mehul Dattani, Krishna Chatterjee and colleagues show that mutations in IGSF1 cause a new X-linked syndrome characterized by central hypothyroidism and testicular enlargement. Their findings implicate IGSF1 as a positive regulator of thyrotropin-releasing hormone signaling in the anterior pituitary.

Yu Sun
Beata Bak
Daniel J Bernard
Research11 Nov 2012
Nature Genetics

Volume: 44, P: 1375-1381
Outcomes of controlled human malaria infection after BCG vaccination

Immune activation induces long-term alterations of setpoints, impacting responses to subsequent unrelated stimuli. Here the authors show that volunteers vaccinated with BCG respond to controlled human malaria infection with increased clinical symptoms and an inverse correlation between immune activation markers and parasitemia.

Jona Walk
L. Charlotte J. de Bree
Robert W. Sauerwein
ResearchOpen Access20 Feb 2019
Nature Communications

Volume: 10, P: 1-8
RETRACTED ARTICLE: Antibodies against endogenous retroviruses promote lung cancer immunotherapy

In lung adenocarcinoma, antibodies against endogenous retroviruses promote anti-tumour activity, and expression of endogenous retroviruses can predict outcomes of immunotherapy.

Kevin W. Ng
Jesse Boumelha
George Kassiotis
ResearchOpen Access12 Apr 2023
Nature

Volume: 616, P: 563-573
Long-period astronomical forcing of mammal turnover

Jan A. van Dam
Hayfaa Abdul Aziz
Pablo Pelaez-Campomanes
Research12 Oct 2006
Nature

Volume: 443, P: 687-691
Using DNA sequencing data to quantify T cell fraction and therapy response

A robust, cost-effective technique based on whole-exome sequencing data can be used to characterize immune infiltrates, relate the extent of these infiltrates to somatic changes in tumours, and enables prediction of tumour responses to immune checkpoint inhibition therapy.

Robert Bentham
Kevin Litchfield
Nicholas McGranahan
Research08 Sept 2021
Nature

Volume: 597, P: 555-560
Rumen microbial community composition varies with diet and host, but a core microbiome is found across a wide geographical range

Gemma Henderson
Faith Cox
Peter H. Janssen
ResearchOpen Access09 Oct 2015
Scientific Reports

Volume: 5, P: 1-15
International scientists formulate a roadmap for insect conservation and recovery

Jeffrey A. Harvey
Robin Heinen
Hans de Kroon
Correspondence06 Jan 2020
Nature Ecology & Evolution

Volume: 4, P: 174-176
In situ study of the formation mechanism of two-dimensional superlattices from PbSe nanocrystals

A real-time study of the growth of two-dimensional nanocrystal superlattices with square periodicity shows the formation mechanism leading to the oriented attachment of the nanocrystals.

Jaco J. Geuchies
Carlo van Overbeek
Daniel Vanmaekelbergh
Research05 Sept 2016
Nature Materials

Volume: 15, P: 1248-1254
A framework for the detection of de novo mutations in family-based sequencing data

Laurent C Francioli
Mircea Cretu-Stancu
Paul IW de Bakker
ResearchOpen Access23 Nov 2016
European Journal of Human Genetics

Volume: 25, P: 227-233
The Genome of the Netherlands: design, and project goals

Dorret I Boomsma
Cisca Wijmenga
Cornelia M van Duijn
ResearchOpen Access29 May 2013
European Journal of Human Genetics

Volume: 22, P: 221-227
Intraluminal oxygen can keep small bowel mucosa intact in a segmental ischemia model

Guido Trentadue
Peter B. F. Mensink
Gisbert Knichwitz
ResearchOpen Access14 Jun 2024
Scientific Reports

Volume: 14, P: 1-9
Population-specific genotype imputations using minimac or IMPUTE2

This protocol describes how to perform SNP imputations for GWAS meta-analysis with the Genome of the Netherlands reference panel using Minimac or IMPUTE2.

Elisabeth M van Leeuwen
Alexandros Kanterakis
Jouke Jan Hottenga
Protocols30 Jul 2015
Nature Protocols

Volume: 10, P: 1285-1296
Methane prediction equations including genera of rumen bacteria as predictor variables improve prediction accuracy

Boyang Zhang
Shili Lin
Zhongtang Yu
ResearchOpen Access02 Dec 2023
Scientific Reports

Volume: 13, P: 1-11
Plaque burden is associated with minimal intimal coverage following drug-eluting stent implantation in an adult familial hypercholesterolemia swine model

Francesca Razzi
Jouke Dijkstra
Heleen M. M. van Beusekom
ResearchOpen Access01 Jul 2023
Scientific Reports

Volume: 13, P: 1-10
WGS-based telomere length analysis in Dutch family trios implicates stronger maternal inheritance and a role for RRM1 gene

Lilit Nersisyan
Maria Nikoghosyan
Arsen Arakelyan
ResearchOpen Access10 Dec 2019
Scientific Reports

Volume: 9, P: 1-9
Glomerular clusterin expression is increased in diabetic nephropathy and protects against oxidative stress-induced apoptosis in podocytes

Junling He
Kyra L. Dijkstra
Hans J. Baelde
ResearchOpen Access10 Sept 2020
Scientific Reports

Volume: 10, P: 1-11
Skewed X-inactivation is common in the general female population

Ekaterina Shvetsova
Alina Sofronova
C Wijmenga
ResearchOpen Access14 Dec 2018
European Journal of Human Genetics

Volume: 27, P: 455-465
Genetic and phenotypic analysis of the pathogenic potential of two novel Chlamydia gallinacea strains compared to Chlamydia psittaci

Marloes Heijne
Martina Jelocnik
Ad P. Koets
ResearchOpen Access13 Aug 2021
Scientific Reports

Volume: 11, P: 1-12
Vascular Cell Adhesion Molecule-1 Is a Key Adhesion Molecule in Melanoma Cell Adhesion to the Leptomeninges

Dieta Brandsma
Jaap C Reijneveld
Emile E Voest
Research01 Nov 2002
Laboratory Investigation

Volume: 82, P: 1493-1502
Hand dexterity, daily functioning and health-related quality of life in kidney transplant recipients

Tim J. Knobbe
Daan Kremer
Stephan J. L. Bakker
ResearchOpen Access28 Sept 2022
Scientific Reports

Volume: 12, P: 1-10
Erratum: Rumen microbial community composition varies with diet and host, but a core microbiome is found across a wide geographical range

Gemma Henderson
Faith Cox
Peter H. Janssen
Amendments and CorrectionsOpen Access20 Jan 2016
Scientific Reports

Volume: 6, P: 1-2
Blood pressure and anthropometrics of 4-y-old children born after preimplantation genetic screening: follow-up of a unique, moderately sized, randomized controlled trial

Jorien Seggers
Maaike L. Haadsma
Mijna Hadders-Algra
Research15 Aug 2013
Pediatric Research

Volume: 74, P: 606-614

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