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Showing 1–8 of 8 results
Advanced filters: Author: Jan Faix Clear advanced filters

  • Amoeboid motility is driven by actomyosin-based contraction and exploits differences in the mechanical properties of the cortical cytoskeleton. Here the authors discover that mDia1-like formin A is responsible for generating a subset of actin filaments at the rear of Dictyosteliumthat suppresses lateral protrusions and blebbing during 2D-confined migration.

    • Nagendran Ramalingam
    • Christof Franke
    • Jan Faix
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-15

  • Actin polymerization in lamellipodia of cells is regulated by the Arp2/3 complex and FMNL family formins. Here the authors show that both FMNL2 and FMNL3 contribute to lamellipodium protrusion and structure, and abolishing FMNL2/3 reduces protrusion force generation and migration, without affecting Arp2/3 incorporation.

    • Frieda Kage
    • Moritz Winterhoff
    • Klemens Rottner
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-16

  • Cell membrane protrusions and invaginations are both driven by actin assembly but the mechanism leading to different membrane shapes is unknown. Using a minimal system and modelling the authors reconstitute the deformation modes and identify capping protein as a regulator of both deformation types.

    • Katharina Dürre
    • Felix C. Keber
    • Andreas R. Bausch
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-11

  • A new protein, Arpin, is identified that inhibits the Arp2/3 complex and controls cell migration by decreasing cell speed and the directional persistence of migration; this inhibitory circuit is under the control of the small GTPase Rac1, and Arpin depletion causes faster lamellipodia protrusion and increased cell migration.

    • Irene Dang
    • Roman Gorelik
    • Alexis Gautreau
    Research
    Nature
    Volume: 503, P: 281-284

  • Genome analysis and molecular cell biology studies indicate that SPIRE actin nucleators originated in unicellular ancestors of animals, providing an actin-myosin driven exocytic transport mechanism that may have contributed to animal evolution.

    • Martin Kollmar
    • Tobias Welz
    • Eugen Kerkhoff
    ResearchOpen Access
    Communications Biology
    Volume: 7, P: 1-21