Strained carbo- and heterocycles are essential motifs in medicinal chemistry and drug discovery, however, their selective functionalization remains challenging. Here, the authors develop a one-pot strategy to access stereo-defined trisubstituted azetidines, cyclobutanes, and five-membered carbo- and heterocycles based on the polar radical crossover of borate derivatives.
- Florian Trauner
- Rahma Ghazali
- Dorian Didier
