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Showing 1–3 of 3 results
Advanced filters: Author: Jan Hellert Clear advanced filters

  • Rabies virus (RABV) infection of unvaccinated individuals can be treated with post exposure prophylaxis. Here, Hellert et al. analyze the structure of a broadly neutralizing human antibody in complex with its target domain in the RABV glycoprotein and demonstrate that it blocks the acid-induced conformational change required for membrane fusion.

    • Jan Hellert
    • Julian Buchrieser
    • Félix A. Rey
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-8

  • Orthobunyaviruses (OBVs) cause severe disease in humans and farm animals, but the molecular basis for infection is not fully understood. Here, the authors present crystal structures of free and antibody-bound OBV envelope glycoproteins and show that their domains enable efficient immunization in a mouse model.

    • Jan Hellert
    • Andrea Aebischer
    • Félix A. Rey
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-14