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Showing 1–4 of 4 results
Advanced filters: Author: Jan Jiricek Clear advanced filters

  • Candidate anti-tuberculosis drugs are often identified in whole-cell screens. Here, Petheet al. show that inappropriate carbon-source selection can lead to the identification of compounds devoid of efficacy in vivo, underlining the importance of developing predictive in vitroscreens.

    • Kevin Pethe
    • Patricia C. Sequeira
    • Thomas Dick
    ResearchOpen Access
    Nature Communications
    Volume: 1, P: 1-8

  • Tuberculosis kills more than a million people annually, and new treatments are necessary to counter the spread of drug-resistant forms of Mycobacterium tuberculosis. In this issue, Kevin Pethe and his colleagues report their identification of a new antibercular drug, called Q203, that targets the mycobacterial cytochrome bc1 complex and that showed efficacy in vitro and in vivo.

    • Kevin Pethe
    • Pablo Bifani
    • Jaeseung Kim
    Research
    Nature Medicine
    Volume: 19, P: 1157-1160

  • The vibroacoustic and chemical alarm communication in the wood roach Cryptocercus and in 20 termite species are studied to reveal that the Neoisoptera species have developed the most sophisticated communication system, which could contribute towards their ecological success.

    • David Sillam-Dussès
    • Vojtěch Jandák
    • Jan Šobotník
    ResearchOpen Access
    Communications Biology
    Volume: 6, P: 1-12